Targeting autophagy in ischemic stroke: from molecular mechanisms to clinical therapeutics

A Ajoolabady, S Wang, G Kroemer… - Pharmacology & …, 2021 - Elsevier
Stroke constitutes the second leading cause of death and a major cause of disability
worldwide. Stroke is normally classified as either ischemic or hemorrhagic stroke (HS) …

The emerging role of miRNAs in Merkel cell carcinoma pathogenesis: Signaling pathway crosstalk

NI Rizk, HM Midan, GK Helal, AI Abulsoud… - … -Research and Practice, 2023 - Elsevier
Merkel cell carcinoma (MCC) is an uncommon invasive form of skin cancer that typically
manifests as a nodule on the face, head, or neck that is flesh-colored or bluish-red in …

miR-182-5p and miR-378a-3p regulate ferroptosis in I/R-induced renal injury

C Ding, X Ding, J Zheng, B Wang, Y Li, H Xiang… - Cell death & …, 2020 - nature.com
Renal tubular cell death is the key factor of the pathogenesis of ischemia/reperfusion (I/R)
kidney injury. Ferroptosis is a type of regulated cell death (RCD) found in various diseases …

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif… - autophagy, 2021 - Taylor & Francis
In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Autophagy and apoptosis cascade: which is more prominent in neuronal death?

R Gupta, RK Ambasta, P Kumar - Cellular and molecular life sciences, 2021 - Springer
Autophagy and apoptosis are two crucial self-destructive processes that maintain cellular
homeostasis, which are characterized by their morphology and regulated through signal …

APF lncRNA regulates autophagy and myocardial infarction by targeting miR-188-3p

K Wang, CY Liu, LY Zhou, JX Wang, M Wang… - Nature …, 2015 - nature.com
The abnormal autophagy is associated with a variety of cardiovascular diseases. Long
noncoding RNAs (lncRNAs) are emerging as new factors in gene regulation, but how …

The Beclin 1 network regulates autophagy and apoptosis

R Kang, HJ Zeh, MT Lotze, D Tang - Cell Death & Differentiation, 2011 - nature.com
Beclin 1, the mammalian orthologue of yeast Atg6, has a central role in autophagy, a
process of programmed cell survival, which is increased during periods of cell stress and …

[HTML][HTML] MicroRNAs in apoptosis, autophagy and necroptosis

Z Su, Z Yang, Y Xu, Y Chen, Q Yu - Oncotarget, 2015 - ncbi.nlm.nih.gov
MicroRNAs (miRNAs) are endogenous 22 nt non-coding RNAs that target mRNAs for
cleavage or translational repression. Numerous miRNAs regulate programmed cell death …

The return of the nucleus: transcriptional and epigenetic control of autophagy

J Füllgrabe, DJ Klionsky, B Joseph - Nature reviews Molecular cell …, 2014 - nature.com
Autophagy is a conserved process by which cytoplasmic components are degraded by the
lysosome. It is commonly seen as a cytoplasmic event and, until now, nuclear events were …

Functions of autophagy in normal and diseased liver

MJ Czaja, WX Ding, TM Donohue, SL Friedman… - Autophagy, 2013 - Taylor & Francis
Autophagy has emerged as a critical lysosomal pathway that maintains cell function and
survival through the degradation of cellular components such as organelles and proteins …