Macrophages, which have functions of engulfing and digesting foreign substances, can
clear away harmful matter, including cellular debris and tumor cells. Based on the condition …

Tumor microenvironment (TME) is composed of tumor cells and surrounding non-tumor
stromal cells, mainly including tumor associated macrophages (TAMs), endothelial cells …

The tumor microenvironment (TME) is essential for immune escape by tumor cells. It plays
essential roles in tumor development and metastasis. The clinical outcomes of tumors are …

Abstract Background Tumor-associated macrophages (TAMs) are known to play important
roles in the initiation and progression of human cancers, as well as in angiogenesis. TAMs …

M2-polarized tumor-associated macrophages (TAMs) are key regulators of the link between
inflammation and cancer. A negative correlation between infiltration intensity of M2 …

One of the hallmarks of cancer‐related inflammation is the recruitment of monocyte‐
macrophage lineage cells to the tumor microenvironment. These tumor infiltrating myeloid …

In the tumor microenvironment (TME), tumor-associated macrophages (TAMs) are the most
abundant immune cells, which act as a key regulator in tumorigenesis and progression …

Tumor microenvironment is composed of proliferating neoplastic cells, a vascular network of
endothelial cells, extra cellular matrix produced by fibroblasts, cellular compartments of …

The innate immune pathway is receiving increasing attention in cancer therapy. This
pathway is ubiquitous across various cell types, not only in innate immune cells but also in …

Macrophages are key innate immune cells in the tumor microenvironment (TME) that
regulate primary tumor growth, vascularization, metastatic spread and tumor response to …