Aims The expression of GADD153 (growth arrest and DNA damage-inducible gene 153), an
apoptosis-regulated gene, increases during endoplasmic reticulum (ER) stress. How …

Document Reviewers: Luis Alcocer (Mexico), Christina Antza (Greece), Mustafa Arici
(Turkey), Eduardo Barbosa (Brazil), Adel Berbari (Lebanon), Luıs Bronze (Portugal), John …

Hypertension is a major risk factor for heart attack, produce atherosclerosis (hardening of the
arteries), congestive heart failure, stroke, kidney infection, blindness, end-stage renal …

Importance The appropriate treatment target for systolic blood pressure (SBP) in older
patients with hypertension remains uncertain. Objective To evaluate the effects of intensive …

Background Hypertension is one of the major causes of many diseases, such as heart
attack, strokes, kidney failure, and many internal disorders. This presentresearch study …

La tarea de elaboración de GPC incluye la creación de herramientas educativas y
programas de implementación de las recomendaciones. Para su implementación, se …

Background Optimal drug treatment for patients with resistant hypertension is undefined. We
aimed to test the hypotheses that resistant hypertension is most often caused by excessive …

Guidelines summarize and evaluate available evidence with the aim of assisting health
professionals in selecting the best management strategies for an individual patient with a …

Effective treatment of systolic hypertension in elderly patients remains a major therapeutic
challenge. A multicenter, double-blind, randomized controlled trial with sacubitril/valsartan …

Background: Identification and treatment of hypertension in China remain suboptimal
despite high prevalence of hypertension and increasing incidence of stroke and myocardial …