Mycobacterium tuberculosis (Mtb) is an extremely successful intracellular pathogen that
causes tuberculosis (TB), which remains the leading infectious cause of human death. The …

Nanozymes are next-generation artificial enzymes having distinguished features such as
cost-effective, enhanced surface area, and high stability. However, limited selectivity and …

Profiling the nascent cellular proteome and capturing early proteomic changes in response
to external stimuli provides valuable insights into cellular physiology. Existing metabolic …

Developments in microscopy have been instrumental to progress in the life sciences, and
many new techniques have been introduced and led to new discoveries throughout the last …

Membrane contact sites (MCS) are intracellular regions where two organelles come closer
to exchange information and material. The majority of the endoplasmic reticulum (ER) MCS …

System-level analysis of single-cell data is rapidly transforming the field of
immunometabolism. Given the competitive demand for nutrients in immune …

Cholesterol import in mammalian cells is mediated by the LDL receptor pathway. Here, we
perform a genome-wide CRISPR screen using an endogenous cholesterol reporter and …

Metabolic labeling of proteins with non-canonical amino acids (ncAAs) provides unique
bioorthogonal chemical groups during de novo synthesis by taking advantage of both …

Progress made in peptide-based vaccinations to induce T-cell-dependent immune
responses against cancer has invigorated the search for optimal vaccine modalities. Design …

Mycobacterium tuberculosis (Mtb) can become a long-term infection by evading the host
immune response. Coevolution of Mtb with humans has resulted in its ability to hijack the …