People of African ancestry who carry the APOL1 risk alleles G1 or G2 are at high risk of
developing kidney diseases through not fully understood mechanisms that impair the …

The podocyte slit diaphragm (SD) is an essential component of the glomerular filtration
barrier and its disruption is a common cause of proteinuria and many types of kidney …

Diabetes is a metabolic disorder characterized by high blood glucose levels and is a leading
cause of kidney disease. Diabetic nephropathy has been attributed to dysfunctional …

Mitochondria are crucial for cellular ATP production. They are highly dynamic organelles,
whose morphology and function are controlled through mitochondrial fusion and fission. The …

Abstract Background The Slit diaphragm (SD) is the key filtration structure in human
glomerular kidney that is affected in many types of renal diseases. SD proteins are known to …

Drosophila nephrocytes are an emerging model system for mammalian podocytes and
proximal tubules as well as for the investigation of kidney diseases. Like podocytes …

Proper balance of exocytosis and endocytosis is important for the maintenance of plasma
membrane lipid and protein homeostasis. This is especially critical in human podocytes and …

Protein reabsorption in renal proximal tubules is essential for maintaining nutrient
homeostasis. Renal proximal tubule-specific gene knockout is a powerful method to assess …

Background Podocyte slit diaphragms (SDs) are intercellular junctions that function as size-
selective filters, excluding most proteins from urine. Abnormalities in SDs cause proteinuria …

Within a cell, vesicles play a crucial role in the transport of membrane material and proteins
to a given target membrane, and thus regulate a variety of cellular functions. Vesicular …