The prevalence of diabetes worldwide is at pandemic levels, with the number of patients
increasing by 5% annually. The most common complication of diabetes is peripheral …

Progressive multiple sclerosis (MS) is a severely disabling neurological condition, and an
effective treatment is urgently needed. Recently, high-dose biotin has emerged as a …

Pain models in animals have shown low predictivity for analgesic efficacy in humans, and
clinical studies are often very confounded, blurring the evaluation. Human experimental pain …

Measurement of axonal excitability provides an in vivo indication of the properties of the
nerve membrane and of the ion channels expressed on these axons. Axonal excitability …

Duplication of the gene encoding the peripheral myelin protein of 22 kDa (PMP22) underlies
the most common inherited neuropathy, Charcot-Marie-Tooth 1A (CMT1A),,, a disease …

Loss-of-function mutations in Na V 1.7 cause congenital insensitivity to pain (CIP); this
voltage-gated sodium channel is therefore a key target for analgesic drug development …

Abstract Learning Objectives After completing this course, the reader will be able to: Define
the symptoms of sensory neurotoxicity in oxaliplatin‐treated patients and identify the long …

Most spiking neurons are divided into functional compartments: a dendritic input region, a
soma, a site of action potential initiation, an axon trunk and its collaterals for propagation of …

Riluzole, a benzothiazole derivative, has been shown to be effective in prolonging survival
in amyotrophic lateral sclerosis. The mechanisms by which riluzole exerts neuroprotective …

Magnetic stimulation is a non-invasive neurostimulation technique that can evoke action
potentials and modulate neural circuits through induced electric fields. Biophysical models …