[HTML][HTML] Can we use eplets (or molecular) mismatch load analysis to improve organ allocation? The hope and the hype

AR Tambur, R Das - Transplantation, 2023 - journals.lww.com
In recent years, there have been calls for implementation of “epitope matching” in deceased-
donor organ allocation policies (later changed to “eplet matching”). Emerging data indeed …

Pediatric kidney transplantation—Can we do better? The promise and limitations of Epitope/Eplet matching

O Charnaya, D Levy Erez, S Amaral… - Frontiers in Pediatrics, 2022 - frontiersin.org
Kidney transplant is the optimal treatment for end-stage kidney disease as it offers significant
survival and quality of life advantages over dialysis. While recent advances have …

Combined Analysis of HLA Class II eplet mismatch and tacrolimus levels for the prediction of de novo donor specific antibody development in kidney transplant …

H Lee, JW Min, H Kang, H Lee, SH Eum, Y Park… - International Journal of …, 2022 - mdpi.com
We investigated whether HLA class II eplet mismatch was related to dnDSA development
and analyzed its combined impact with tacrolimus levels for kidney transplantation …

HLA B eplet mismatches in the context of delayed graft function and low tacrolimus trough levels are risk factors influencing the generation of de novo donor-specific …

S Gao, H Gong, M Li, P Lan, M Zhang, P Kuang… - Transplant …, 2023 - Elsevier
Background De novo donor-specific antibody (dnDSA) generation and acute rejection (AR)
are the main factors affecting long-term graft survival. This study aims to investigate human …