Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia
T Sanda, LN Lawton, MI Barrasa, ZP Fan… - Cancer cell, 2012 - cell.com
The oncogenic transcription factor TAL1/SCL is aberrantly expressed in over 40% of cases
of human T cell acute lymphoblastic leukemia (T-ALL), emphasizing its importance in the …
of human T cell acute lymphoblastic leukemia (T-ALL), emphasizing its importance in the …
Characterization of transcriptional networks in blood stem and progenitor cells using high-throughput single-cell gene expression analysis
V Moignard, IC Macaulay, G Swiers, F Buettner… - Nature cell …, 2013 - nature.com
Cellular decision-making is mediated by a complex interplay of external stimuli with the
intracellular environment, in particular transcription factor regulatory networks. Here we have …
intracellular environment, in particular transcription factor regulatory networks. Here we have …
Transcriptional regulation of haematopoietic transcription factors
The control of differential gene expression is central to all metazoan biology.
Haematopoiesis represents one of the best understood developmental systems where …
Haematopoiesis represents one of the best understood developmental systems where …
Occupancy by key transcription factors is a more accurate predictor of enhancer activity than histone modifications or chromatin accessibility
Background Regulated gene expression controls organismal development, and variation in
regulatory patterns has been implicated in complex traits. Thus accurate prediction of …
regulatory patterns has been implicated in complex traits. Thus accurate prediction of …
Genome-wide transcription factor–binding maps reveal cell-specific changes in the regulatory architecture of human HSPCs
Hematopoietic stem and progenitor cells (HSPCs) rely on a complex interplay among
transcription factors (TFs) to regulate differentiation into mature blood cells. A heptad of TFs …
transcription factors (TFs) to regulate differentiation into mature blood cells. A heptad of TFs …
An experimentally validated network of nine haematopoietic transcription factors reveals mechanisms of cell state stability
Transcription factor (TF) networks determine cell-type identity by establishing and
maintaining lineage-specific expression profiles, yet reconstruction of mammalian regulatory …
maintaining lineage-specific expression profiles, yet reconstruction of mammalian regulatory …
Transcriptional hierarchies regulating early blood cell development
V Moignard, S Woodhouse, J Fisher… - Blood Cells, Molecules …, 2013 - Elsevier
Hematopoiesis represents one of the paradigmatic systems for studying stem cell biology,
but our understanding of how the hematopoietic system develops during embryogenesis is …
but our understanding of how the hematopoietic system develops during embryogenesis is …
[HTML][HTML] A compendium of genome-wide hematopoietic transcription factor maps supports the identification of gene regulatory control mechanisms
OBJECTIVE: Key regulators of blood stem cell differentiation into the various mature
hematopoietic lineages are commonly encoded by transcription factor genes. Elucidation of …
hematopoietic lineages are commonly encoded by transcription factor genes. Elucidation of …
Impaired In Vitro Erythropoiesis following Deletion of the Scl (Tal1) +40 Enhancer Is Largely Compensated for In Vivo despite a Significant Reduction in Expression
R Ferreira, D Spensberger, Y Silber… - … and cellular biology, 2013 - Taylor & Francis
The Scl (Tal1) gene encodes a helix-loop-helix transcription factor essential for
hematopoietic stem cell and erythroid development. The Scl+ 40 enhancer is situated …
hematopoietic stem cell and erythroid development. The Scl+ 40 enhancer is situated …
Establishing the stem cell state: insights from regulatory network analysis of blood stem cell development
J Schütte, V Moignard… - … Reviews: Systems Biology …, 2012 - Wiley Online Library
Transcription factors (TFs) have long been recognized as powerful regulators of cell‐type
identity and differentiation. As TFs function as constituents of regulatory networks …
identity and differentiation. As TFs function as constituents of regulatory networks …