Induction, detection, formation, and resuscitation of viable but non‐culturable state microorganisms

K Dong, H Pan, D Yang, L Rao, L Zhao… - … Reviews in Food …, 2020 - Wiley Online Library
The viable but nonculturable (VBNC) state has been recognized as a strategy for bacteria to
cope with stressful environments; in this state, bacteria fail to grow on routine culture …

Relationship between the viable but nonculturable state and antibiotic persister cells

M Ayrapetyan, T Williams, JD Oliver - Journal of bacteriology, 2018 - Am Soc Microbiol
Bacteria have evolved numerous means of survival in adverse environments with dormancy,
as represented by “persistence” and the “viable but nonculturable”(VBNC) state, now …

Bacterial persisters are a stochastically formed subpopulation of low-energy cells

S Manuse, Y Shan, SJ Canas-Duarte, S Bakshi… - PLoS …, 2021 - journals.plos.org
Persisters represent a small subpopulation of non-or slow-growing bacterial cells that are
tolerant to killing by antibiotics. Despite their prominent role in the recalcitrance of chronic …

[HTML][HTML] Dawning of a new ERA: Environmental Risk Assessment of antibiotics and their potential to select for antimicrobial resistance

AK Murray, I Stanton, WH Gaze, J Snape - Water Research, 2021 - Elsevier
Antibiotics and antimicrobials are used, misused and overused in human and veterinary
medicine, animal husbandry and aquaculture. These compounds can persist in both human …

Detection of OXA-48 Gene in Carbapenem-Resistant Escherichia coli and Klebsiella pneumoniae from Urine Samples

S Gurung, S Kafle, B Dhungel, N Adhikari… - Infection and drug …, 2020 - Taylor & Francis
Introduction Resistance to carbapenem in Gram-negative bacteria is attributable to their
ability to produce carbapenemase enzymes. The main objective of this study was to detect …

Bacteriostatic antibiotics promote CRISPR-Cas adaptive immunity by enabling increased spacer acquisition

T Dimitriu, E Kurilovich, U Łapińska, K Severinov… - Cell host & …, 2022 - cell.com
Phages impose strong selection on bacteria to evolve resistance against viral predation.
Bacteria can rapidly evolve phage resistance via receptor mutation or using their CRISPR …

Persister Escherichia coli cells have a lower intracellular pH than susceptible cells but maintain their pH in response to antibiotic treatment

O Goode, A Smith, A Zarkan, J Cama, BM Invergo… - MBio, 2021 - Am Soc Microbiol
Persister and viable but non-culturable (VBNC) cells are two clonal subpopulations that can
survive multidrug exposure via a plethora of putative molecular mechanisms. Here, we …

Host cell oxidative stress induces dormant Staphylococcus aureus persisters

F Peyrusson, TK Nguyen, T Najdovski… - Microbiology …, 2022 - Am Soc Microbiol
Persisters are transiently nongrowing and antibiotic-tolerant phenotypic variants identified in
major human pathogens, including intracellular Staphylococcus aureus. Due to their …

Fast bacterial growth reduces antibiotic accumulation and efficacy

U Łapińska, M Voliotis, KK Lee, A Campey, MRL Stone… - Elife, 2022 - elifesciences.org
Phenotypic variations between individual microbial cells play a key role in the resistance of
microbial pathogens to pharmacotherapies. Nevertheless, little is known about cell …

Microfluidics for antibiotic susceptibility testing

W Postek, N Pacocha, P Garstecki - Lab on a Chip, 2022 - pubs.rsc.org
The rise of antibiotic resistance is a threat to global health. Rapid and comprehensive
analysis of infectious strains is critical to reducing the global use of antibiotics, as informed …