The presence of impurities in active pharmaceutical ingredients (APIs) and drug products
represents a risk to patients' health. Such substances are related to diverse side effects and …

Forced degradation studies have been used to simplify analytical methodology development
and achieve a deeper knowledge about the inherent stability of active pharmaceutical …

The present study focused on the forced degradation behavior of sertraline hydrochloride
(SRT), selective serotonin reuptake inhibitor (SSRI). The drug was exposed to different …

Dabrafenib (Tafinlar) is used for the treatment of patients with BRAF V600 mutation positive
unresectable or metastatic melanoma. Forced degradation study of the drug product and …

Belinostat is a histone deacetylase inhibitor used for the management of hematological
malignancies and solid tumors. In the current study, stability-indicating ultra-performance …

Ibrutinib, an antineoplastic agent tackling chronic lymphocytic leukemia, mantle cell
lymphoma, and Waldenstrom's Macroglobulinemia, falls under the category of BCS class II …

Post-harvest processing is a leading cause of metabolic changes and quality loss in food
products. An untargeted metabolomics approach based on UHPLC-QTOF-MS was …

Forced degradation studies of d-tubocurarine (DTC) was carried out in hydrolytic (acidic,
alkaline and neutral), thermal, photolytic and oxidative degradation conditions as per …

In present study, a novel, simple, robust, stability-indicating, highly sensitive and specific
reverse phase ultra-performance liquid chromatographic method was established and …

Objectives: Dabrafenib is used as an active pharmaceutical ingredient acts as an inhibitor of
the associated enzyme B-Raf, which plays a role in the regulation of cell growth. In the …