Highlights•Structure-based strategies allow more-specific targeting of protein–protein
interactions (PPIs).•Interfering peptides (IPs) become a promising alternative to small …

Organic chemists working on the synthesis of natural products have long found a special
challenge in the preparation of peptides and proteins. However, more reliable, more efficient …

The elaboration of peptide libraries prepared by either chemical or biological methods in a
format useful for discovery of peptides with specific biological activities was first introduced …

The Nucleocapsid (N) protein is highlighted as the main target for COVID-19 diagnosis by
antigen detection due to its abundance in circulation early during infection. However, the …

This review begins with a brief discussion of the biological importance and chemical
features of peptides. A description of the existing synthetic methods follows with emphasis …

The thyroid hormone receptor regulates a diverse set of genes that control processes from
embryonic development to adult homeostasis. Upon binding of thyroid hormone, the thyroid …

Background Orthohantavirus infection is a neglected global health problem affecting
approximately 200,000 people/year, spread by rodent hosts and associated to fatal human …

Sphingomyelin is a major constituent of eukaryotic cell membranes, and if degraded by
bacteria sphingomyelinases may contribute to the pathogenesis of infection. Among …

PEPscan is an old approach that has recently gained renewed interest for the identification
of interfering peptides (IPs), ie, peptides able to interfere with protein–protein interactions …

A new computational method (EpiDock) is proposed for predicting peptide binding to class I
MHC proteins, from the amino acid sequence of any protein of immunological interest …