Strategies used by bacteria to grow in macrophages

G Mitchell, C Chen, DA Portnoy - Myeloid Cells in Health and …, 2017 - Wiley Online Library
Intracellular bacterial pathogens cause a wide range of diseases and significantly contribute
to the morbidity and mortality associated with infectious diseases worldwide (1‐16)(Table 1) …

Subversion of retrograde trafficking by translocated pathogen effectors

N Personnic, K Bärlocher, I Finsel, H Hilbi - Trends in microbiology, 2016 - cell.com
Intracellular bacterial pathogens subvert the endocytic bactericidal pathway to form specific
replication-permissive compartments termed pathogen vacuoles or inclusions. To this end …

Mechanisms of host cell exit by the intracellular bacterium Chlamydia

K Hybiske, RS Stephens - Proceedings of the national …, 2007 - National Acad Sciences
The mechanisms that mediate the release of intracellular bacteria from cells are poorly
understood, particularly for those that live within a cellular vacuole. The release pathway of …

[HTML][HTML] Sequence-based prediction of type III secreted proteins

R Arnold, S Brandmaier, F Kleine, P Tischler… - PLoS …, 2009 - journals.plos.org
The type III secretion system (TTSS) is a key mechanism for host cell interaction used by a
variety of bacterial pathogens and symbionts of plants and animals including humans. The …

Histone Methylation by NUE, a Novel Nuclear Effector of the Intracellular Pathogen Chlamydia trachomatis

ME Pennini, S Perrinet, A Dautry-Varsat… - PLoS …, 2010 - journals.plos.org
Sequence analysis of the genome of the strict intracellular pathogen Chlamydia trachomatis
revealed the presence of a SET domain containing protein, proteins that primarily function …

Accurate prediction of secreted substrates and identification of a conserved putative secretion signal for type III secretion systems

R Samudrala, F Heffron, JE McDermott - PLoS pathogens, 2009 - journals.plos.org
The type III secretion system is an essential component for virulence in many Gram-negative
bacteria. Though components of the secretion system apparatus are conserved, its …

The Chlamydia effector CpoS modulates the inclusion microenvironment and restricts the interferon response by acting on Rab35

K Meier, LH Jachmann, G Türköz, MR Babu Sait… - MBio, 2023 - Am Soc Microbiol
The obligate intracellular bacterium Chlamydia trachomatis inserts a family of inclusion
membrane (Inc) proteins into the membrane of its vacuole (the inclusion). The Inc CpoS is a …

A small-molecule inhibitor of type III secretion inhibits different stages of the infectious cycle of Chlamydia trachomatis

S Muschiol, L Bailey, Å Gylfe… - Proceedings of the …, 2006 - National Acad Sciences
The intracellular pathogen Chlamydia trachomatis possesses a type III secretion (TTS)
system believed to deliver a series of effector proteins into the inclusion membrane (Inc …

Type III secretion a la Chlamydia

J Peters, DP Wilson, G Myers, P Timms, PM Bavoil - Trends in microbiology, 2007 - cell.com
Type III secretion (T3S) is a mechanism that is central to the biology of the Chlamydiaceae
and many other pathogens whose virulence depends on the translocation of toxic effector …

Expression and targeting of secreted proteins from Chlamydia trachomatis

LD Bauler, T Hackstadt - Journal of bacteriology, 2014 - Am Soc Microbiol
Chlamydia trachomatis is an obligate intracellular pathogen that replicates in a vacuole
termed the inclusion. Many of the interactions of chlamydiae with the host cell are dependent …