Arterial hypertension–Clinical trials update 2021

H Al Ghorani, F Goetzinger, M Boehm… - Nutrition, Metabolism and …, 2022 - Elsevier
Aim This review aims to summarize and discuss some of the most relevant clinical trials in
epidemiology, diagnostics, and treatment of hypertension published in 2020 and 2021. Data …

Nocturnal hypertension and heart failure: mechanisms, evidence, and new treatments

K Kario, B Williams - Hypertension, 2021 - Am Heart Assoc
Heart failure (HF) is a common condition with an increasing prevalence. Despite a variety of
evidence-based treatments for patients with HF with reduced ejection fraction, morbidity and …

Renal denervation in hypertension patients: proceedings from an expert consensus roundtable cosponsored by SCAI and NKF

DE Kandzari, RR Townsend, G Bakris… - Catheterization and …, 2021 - Wiley Online Library
Despite the availability of efficacious pharmacological treatments, hypertension remains the
leading global cause of death and disability, 1 and rates of blood pressure (BP) control are …

Renal denervation in the antihypertensive arsenal–knowns and known unknowns

FH Messerli, C Bavishi, J Brguljan, M Burnier… - Journal of …, 2022 - journals.lww.com
Even though it has been more than a decade since renal denervation (RDN) was first used
to treat hypertension and an intense effort on researching this therapy has been made, it is …

Histological examination of renal nerve distribution, density, and function in humans

H Struthoff, L Lauder, M Hohl, A Hermens… - …, 2023 - pmc.ncbi.nlm.nih.gov
Background Renal denervation is optimised when guided by knowledge of nerve
distribution. Aims We aimed to assess sympathetic nerve distribution along the renal …

The current status of renal denervation for the treatment of arterial hypertension

L Lauder, M Boehm, F Mahfoud - Progress in Cardiovascular Diseases, 2021 - Elsevier
Despite the availability of safe and effective antihypertensive drugs, blood pressure (BP)
control to guideline-recommended target values is poor. Several device-based therapies …

Current problems in renal denervation and a hope to break the stage

X Hu, H Zhou, W Chen, D Li, H Du, T Xia… - Hypertension Research, 2023 - nature.com
Renal denervation (RDN) is currently confronted with the considerable heterogeneity of
different post-procedural blood pressure responses. The challenges predominantly arise …

Twenty-four-hour pulsatile hemodynamics predict brachial blood pressure response to renal denervation in the SPYRAL HTN-OFF MED Trial

T Weber, S Wassertheurer, CC Mayer, B Hametner… - …, 2022 - Am Heart Assoc
Background: Renal denervation (RDN) lowers blood pressure (BP), but BP response is
variable in individual patients. We investigated whether measures of pulsatile …

Patient‐Specific Factors Predicting Renal Denervation Response in Patients With Hypertension: A Systematic Review and Meta‐Analysis

XR Hu, GZ Liao, JW Wang, YY Ye… - Journal of the …, 2024 - ahajournals.org
Background The accurate selection of patients likely to respond to renal denervation (RDN)
is crucial for optimizing treatment outcomes in patients with hypertension. This systematic …

Present evidence of determinants to predict the efficacy of renal denervation

H Zhou, Y Xu, W Chen, L Wang, H Du… - International Journal …, 2022 - Wiley Online Library
Sympathetic overactivation is one of the main contributors to development and progress of
hypertension. Renal denervation (RDN) has been evidenced by series of clinical trials for its …