Since the initial identification of alpha-synuclein (α-syn) at the synapse, numerous studies
demonstrated that α-syn is a key player in the etiology of Parkinson's disease (PD) and other …

Lysosomal storage disorders (LSDs) are a heterogenous group of disorders due to
genetically determined deficits of lysosomal enzymes. The specific molecular mechanism …

Autophagic impairment was identified in many lysosomal storage diseases and adult
neurodegenerative diseases. It seems that this defect could be directly related to the …

Krabbe disease is an infantile neurodegenerative disorder resulting from pathogenic
variants in the GALC gene that causes accumulation of the toxic sphingolipid psychosine …

Krabbe disease (KD; or globoid cell leukodystrophy) is an autosomal recessive lysosomal
storage disorder caused by deficiency of the galactosylceramidase (GALC) enzyme. No cure …

Since the initial identification of alpha-synuclein (α-syn) at the synapse, numerous studies
demonstrated that α-syn is a key player in the etiology of Parkinson's disease (PD) and other …