Molecular panorama of therapy resistance in prostate cancer: a pre-clinical and bioinformatics analysis for clinical translation

M Ashrafizadeh, W Zhang, Y Tian, G Sethi… - Cancer and Metastasis …, 2024 - Springer
Prostate cancer (PCa) is a malignant disorder of prostate gland being asymptomatic in early
stages and high metastatic potential in advanced stages. The chemotherapy and surgical …

Cancer Stem Cells and Androgen Receptor Signaling: Partners in Disease Progression

JC Quintero, NF Díaz, M Rodríguez-Dorantes… - International Journal of …, 2023 - mdpi.com
Cancer stem cells exhibit self-renewal, tumorigenesis, and a high differentiation potential.
These cells have been detected in every type of cancer, and different signaling pathways …

Role of Wnt/β-catenin pathway in cancer drug resistance: Insights into molecular aspects of major solid tumors

C Samant, R Kale, KSR Pai, K Nandakumar… - Biochemical and …, 2024 - Elsevier
Adaptive resistance to conventional and targeted therapies remains one of the major
obstacles in effective management of cancer. Aberrant activation of key signaling …

[HTML][HTML] Mortalin promotes the evolution of androgen-independent prostate cancer through Wnt/β-catenin signaling pathway

Y Chang, J Sui, Q Fu, Z Lu, Z Piao, T Jin… - Cancer Cell …, 2024 - ncbi.nlm.nih.gov
Prostate cancer (PC) is a major global health concern affecting male individuals. Among its
variants, androgen-independent prostate cancer exhibits slow progression and lacks …

[HTML][HTML] Excavating regulated cell death signatures to predict prognosis, tumor microenvironment and therapeutic response in HR+/HER2-breast cancer

S Mao, Y Zhao, H Xiong, C Gong - Translational Oncology, 2024 - Elsevier
Regulated cell death (RCD) has been documented to have great potentials for discovering
novel biomarkers and therapeutic targets in malignancies. But its role and clinical value in …

Interactions and communications in the prostate tumour microenvironment: evolving towards effective cancer therapy

Q Dai, Y Peng, P He, X Wu - Journal of Drug Targeting, 2024 - Taylor & Francis
Prostate cancer is one of the most common malignancies in men. The tumour
microenvironment (TME) has a critical role in the initiation, progression, and metastasis of …

Expression of OCT4 isoforms is reduced in primary colorectal cancer

E Turyova, P Mikolajcik, M Grendar, E Kudelova… - Frontiers in …, 2023 - frontiersin.org
Introduction Colorectal cancer (CRC) is one of the most common types of cancer worldwide.
The carcinogenesis of CRC is indeed complex, and there are many different mechanisms …

[PDF][PDF] Advancements in Research on Non-AR-Signaling Pathways and Targeted Therapies for Castration-Resistant Prostate Cancer

H Dad, A Hansen - auo.asmepress.com
Prostate cancer (Pca) is a significant malignancy affecting men's health, with its incidence
steadily increasing worldwide in recent years. Among its various subtypes …