Current advance of nanotechnology in diagnosis and treatment for malignant tumors

B Wang, S Hu, Y Teng, J Chen, H Wang, Y Xu… - … and Targeted Therapy, 2024 - nature.com
Cancer remains a significant risk to human health. Nanomedicine is a new multidisciplinary
field that is garnering a lot of interest and investigation. Nanomedicine shows great potential …

Pre-metastatic niche: formation, characteristics and therapeutic implication

Y Wang, J Jia, F Wang, Y Fang, Y Yang… - … and Targeted Therapy, 2024 - nature.com
Distant metastasis is a primary cause of mortality and contributes to poor surgical outcomes
in cancer patients. Before the development of organ-specific metastasis, the formation of a …

Metabolic insights into tumor lymph node metastasis in melanoma

J Huang, Z Gao, J Xuan, N Gao, C Wei, J Gu - Cellular Oncology, 2024 - Springer
Although accounting for only a small amount of skin cancers, melanoma contributes
prominently to skin cancer-related deaths, which are mostly caused by metastatic diseases …

[HTML][HTML] Melanoma-Derived Extracellular Vesicles Induce CD36-Mediated Pre-Metastatic Niche

S Suman, WK Nevala, AA Leontovich, C Ward… - Biomolecules, 2024 - mdpi.com
CD36 expression in both immune and non-immune cells is known to be directly involved in
cancer metastasis. Extracellular vesicles (EVs) secreted by malignant melanocytes play a …

Biomimetic intelligent nanoplatform with cascade amplification effect for tumor synergy therapy

Y Wang, Q Ji, C Yan, P Ji - Scientific Reports, 2024 - nature.com
Tumor heterogeneity, immune-suppressive microenvironment and the precise killing of
tumor cells by drugs are important factors affecting tumor treatment. In this study, we …

Patient‐Derived Melanoma Immune‐Tumoroids as a Platform for Precise High throughput Drug Screening

J Viegas, S Costa, S Dias, CL Pereira… - Advanced …, 2024 - Wiley Online Library
In vitro models are crucial in cancer research, but they must truthfully mimic in vivo tumors for
clinical relevance. The development of unprecedent melanoma quadruple multicellular …

Melanoma-derived cytokines and extracellular vesicles are interlinked with macrophage immunosuppression

S Suman, WK Nevala, AA Leontovich… - Frontiers in Molecular …, 2025 - frontiersin.org
Cytokines play a crucial role in mediating cell communication within the tumor
microenvironment (TME). Tumor-associated macrophages are particularly influential in the …

Targeting Neuropilin-1 to Enhance Immunotherapy in Melanoma: Reducing Tumour Progression and Peripheral Treg-Mediated Immunosuppression

S Khamaru, KS Tung, S Chattopadhyay - bioRxiv, 2024 - biorxiv.org
Melanoma, the most aggressive form of skin cancer with a high mutation rate, is the fifth most
common cancer among Caucasians. Despite advancements in treatments like immune …