Glucocorticoids—all-rounders tackling the versatile players of the immune system

C Strehl, L Ehlers, T Gaber, F Buttgereit - Frontiers in immunology, 2019 - frontiersin.org
Glucocorticoids regulate fundamental processes of the human body and control cellular
functions such as cell metabolism, growth, differentiation, and apoptosis. Moreover …

Harnessing the plasticity of CD4+ T cells to treat immune-mediated disease

M DuPage, JA Bluestone - Nature Reviews Immunology, 2016 - nature.com
CD4+ T cells differentiate and acquire distinct functions to combat specific pathogens but
can also adapt their functions in response to changing circumstances. Although this …

Lactobacillus reuteri induces gut intraepithelial CD4+CD8αα+ T cells

L Cervantes-Barragan, JN Chai, MD Tianero… - Science, 2017 - science.org
The small intestine contains CD4+ CD8αα+ double-positive intraepithelial lymphocytes (DP
IELs), which originate from intestinal CD4+ T cells through down-regulation of the …

The chromatin-modifying enzyme Ezh2 is critical for the maintenance of regulatory T cell identity after activation

M DuPage, G Chopra, J Quiros, WL Rosenthal… - Immunity, 2015 - cell.com
Regulatory T cells (Treg cells) are required for immune homeostasis. Chromatin remodeling
is essential for establishing diverse cellular identities, but how the epigenetic program in …

Logical modeling and dynamical analysis of cellular networks

W Abou-Jaoudé, P Traynard, PT Monteiro… - Frontiers in …, 2016 - frontiersin.org
The logical (or logic) formalism is increasingly used to model regulatory and signaling
networks. Complementing these applications, several groups contributed various methods …

Gene regulatory network modeling of macrophage differentiation corroborates the continuum hypothesis of polarization states

A Palma, AS Jarrah, P Tieri, G Cesareni… - Frontiers in …, 2018 - frontiersin.org
Macrophages derived from monocyte precursors undergo specific polarization processes
which are influenced by the local tissue environment: classically activated (M1) …

T cell receptor signaling in the differentiation and plasticity of CD4+ T cells

HT Meitei, G Lal - Cytokine & Growth Factor Reviews, 2023 - Elsevier
CD4+ T cells are critical components of the adaptive immune system. The T cell receptor
(TCR) and co-receptor signaling cascades shape the phenotype and functions of CD4+ T …

Logical modeling and analysis of cellular regulatory networks with GINsim 3.0

A Naldi, C Hernandez, W Abou-Jaoudé… - Frontiers in …, 2018 - frontiersin.org
The logical formalism is well adapted to model large cellular networks, in particular when
detailed kinetic data are scarce. This tutorial focuses on this well-established qualitative …

An evolutionary perspective on the systems of adaptive immunity

V Müller, RJ De Boer, S Bonhoeffer… - Biological …, 2018 - Wiley Online Library
We propose an evolutionary perspective to classify and characterize the diverse systems of
adaptive immunity that have been discovered across all major domains of life. We put …

Gene regulatory networks exhibit several kinds of memory: Quantification of memory in biological and random transcriptional networks

S Biswas, S Manicka, E Hoel, M Levin - Iscience, 2021 - cell.com
Gene regulatory networks (GRNs) process important information in developmental biology
and biomedicine. A key knowledge gap concerns how their responses change over time …