p53 in the DNA-damage-repair process

AB Williams, B Schumacher - Cold Spring …, 2016 - perspectivesinmedicine.cshlp.org
The cells in the human body are continuously challenged by a variety of genotoxic attacks.
Erroneous repair of the DNA can lead to mutations and chromosomal aberrations that can …

The role of p53 in determining sensitivity to radiotherapy

AV Gudkov, EA Komarova - Nature Reviews Cancer, 2003 - nature.com
Ionizing radiation (IR) has proven to be a powerful medical treatment in the fight against
cancer. Rational and effective use of its killing power depends on understanding IR …

Low-intensity therapy in adults with Burkitt's lymphoma

K Dunleavy, S Pittaluga, M Shovlin… - … England Journal of …, 2013 - Mass Medical Soc
Background Burkitt's lymphoma is an aggressive B-cell lymphoma that occurs in children
and adults and is largely curable with the use of intensive and toxic chemotherapy. Current …

Whole-genome and multisector exome sequencing of primary and post-treatment glioblastoma reveals patterns of tumor evolution

H Kim, S Zheng, SS Amini, SM Virk… - Genome …, 2015 - genome.cshlp.org
Glioblastoma (GBM) is a prototypical heterogeneous brain tumor refractory to conventional
therapy. A small residual population of cells escapes surgery and chemoradiation, resulting …

Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4–CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA

Z Galehdar, P Swan, B Fuerth… - Journal of …, 2010 - Soc Neuroscience
An increasing body of evidence points to a key role of endoplasmic reticulum (ER) stress in
acute and chronic neurodegenerative conditions. Extensive ER stress can trigger neuronal …

Regulation and mechanisms of mammalian double-strand break repair

K Valerie, LF Povirk - Oncogene, 2003 - nature.com
The double-strand break (DSB) is believed to be one of the most severe types of DNA
damage, and if left unrepaired is lethal to the cell. Several different types of repair act on the …

The interacting pathways for prevention and repair of oxidative DNA damage

G Slupphaug, B Kavli, HE Krokan - Mutation Research/Fundamental and …, 2003 - Elsevier
Genomes are damaged by spontaneous decay, chemicals, radiation and replication errors.
DNA damage may cause mutations resulting in inheritable disease, cancer and ageing …

P53 and radiation responses

P Fei, WS El-Deiry - Oncogene, 2003 - nature.com
Cells have evolved elaborate mechanisms (checkpoints) to monitor genomic integrity in
order to ensure the high-fidelity transmission of genetic information. Cells harboring defects …

p53: traffic cop at the crossroads of DNA repair and recombination

S Sengupta, CC Harris - Nature reviews Molecular cell biology, 2005 - nature.com
Abstract p53 mutants that lack DNA-binding activities, and therefore, transcriptional
activities, are among the most common mutations in human cancer. Recently, a new role for …

ATM, ATR and DNA-PK: initiators of the cellular genotoxic stress responses

J Yang, Y Yu, HE Hamrick… - …, 2003 - academic.oup.com
Exposure to genotoxic agents is a major cause of human cancer, and cellular responses to
genotoxic stress are important defense mechanisms. These responses are very complex …