Current Understanding of the Pathophysiology of Osteonecrosis of the Jaw

J Chang, AE Hakam, LK McCauley - Current osteoporosis reports, 2018 - Springer
Abstract Purpose of Review Osteonecrosis of the jaw (ONJ) is a rare and severe necrotic
bone disease reflecting a compromise in the body's osseous healing mechanisms and …

Dental implant placement in patients with a history of medications related to osteonecrosis of the jaws: a systematic review

J Sher, K Kirkham-Ali, JD Luo… - Journal of Oral …, 2021 - meridian.allenpress.com
The present systematic review evaluates the safety of placing dental implants in patients
with a history of antiresorptive or antiangiogenic drug therapy. The Preferred Reporting …

Skeletal Site-specific Effects of Zoledronate on in vivo Bone Remodeling and in vitro BMSCs Osteogenic Activity

X Gong, W Yu, H Zhao, J Su, Q Sheng - Scientific reports, 2017 - nature.com
Bisphosphonate-related osteonecrosis of the jaw (BRONJ) has been associated with long-
term oral or intravenous administration of nitrogen-containing bisphosphonates (BPs) …

Systematic comparison of the effect of four clinical-grade platelet rich hemoderivatives on osteoblast behaviour

T Fernández-Medina, C Vaquette… - International journal of …, 2019 - mdpi.com
Hemoderivatives have utilized in an empirical manner, driven by clinical considerations,
leading to the development of a plethora of manufacturing protocols. The purpose of this …

The case of medication-related osteonecrosis of the jaw addressed from a pathogenic point of view. Innovative therapeutic strategies: Focus on the most recent …

A Giudice, A Antonelli, E Chiarella, F Baudi, T Barni… - Pharmaceuticals, 2020 - mdpi.com
Bisphosphonates-related osteonecrosis of the jaw (BRONJ) was firstly reported by Marx in
2003. Since 2014, the term medication-related osteonecrosis of the jaw (MRONJ) is …

Local delivery of hydrogel encapsulated vascular endothelial growth factor for the prevention of medication-related osteonecrosis of the jaw

D Sharma, S Hamlet, C Vaquette, EB Petcu… - Scientific Reports, 2021 - nature.com
The anti-angiogenic effects of bisphosphonates have been hypothesized as one of the
major etiologic factors in the development of medication-related osteonecrosis of the jaw …

The bisphosphonates alendronate and zoledronate induce adaptations of aerobic metabolism in permanent human endothelial cells

A Budzinska, L Galganski, W Jarmuszkiewicz - Scientific Reports, 2023 - nature.com
Abstract Nitrogen-containing bisphosphonates (NBPs), compounds that are widely used in
the treatment of bone disorders, may cause side effects related to endothelial dysfunction …

The rationale for using neridronate in musculoskeletal disorders: from metabolic bone diseases to musculoskeletal pain

G Iolascon, A Moretti - International Journal of Molecular Sciences, 2022 - mdpi.com
Neridronate or ((6-amino-1-hydroxy-1-phosphonohexyl) phosphonic acid) is an amino-
bisphosphonate (BP) synthetized in Italy in 1986. Bisphosphonates are molecules with a …

Endothelial Progenitor Cells inhibit jaw osteonecrosis in a rat model: A major adverse effect of bisphosphonate therapy

T Tamari, R Elimelech, G Cohen, T Cohen, O Doppelt… - Scientific reports, 2019 - nature.com
Medication-related osteonecrosis of the jaw (MRONJ) is a serious adverse effect of
antiresorptive and antiangiogenic therapies. MRONJ is identified by chronic wounds in the …

[HTML][HTML] A Systematic Review of Laser Photobiomodulation Dosimetry and Treatment Protocols in the Management of Medications-Related Osteonecrosis of the Jaws …

R Hanna, IC Miron, S Dalvi, P Arany… - …, 2024 - pmc.ncbi.nlm.nih.gov
Medication-related osteonecrosis of the jaw (MRONJ) is a debilitating adverse effect of
bisphosphates, antiresorptive therapy or antiangiogenic agents that can potentially increase …