Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Huntington's disease is a late-onset neurodegenerative disease caused by a CAG
trinucleotide repeat in the gene encoding the huntingtin protein. Despite its well-defined …

NMDA receptor (NMDAR)-induced excitotoxicity is thought to contribute to the cell death
associated with certain neurodegenerative diseases, stroke, epilepsy, and traumatic brain …

Neural cultures derived from Huntington's disease (HD) patient-derived induced pluripotent
stem cells were used for'omics' analyses to identify mechanisms underlying …

GluN3-containing NMDA receptors (GluN3-NMDARs) are rarer than the'classical'NMDARs,
which are composed solely of GluN1 and GluN2 subunits, and have non-conventional …

Huntington's disease is an autosomal-dominant neurodegenerative disease caused by CAG
expansion in exon 1 of the huntingtin (HTT) gene. Since mutant huntingtin (mHTT) protein is …

GluN3A is an atypical glycine-binding subunit of NMDA receptors (NMDARs) whose actions
in the brain are mostly unknown. Here, we show that the expression of GluN3A subunits …

GluN3A is a glycine-binding subunit belonging to the NMDA receptor (NMDAR) family that
can assemble with GluN1 subunits to form unconventional NMDARs insensitive to glutamate …

Huntington disease (HD) is an inherited neurodegenerative disorder caused by an
expansion of the CAG repeat region in the first exon of the huntingtin gene …

The purpose of this review is to bridge the gap between earlier literature on striatal
cholinergic interneurons and mechanisms of microcircuit interaction demonstrated with the …