Innate immune evasion strategies of SARS-CoV-2
JM Minkoff, B tenOever - Nature Reviews Microbiology, 2023 - nature.com
Abstract SARS-CoV-2, the virus responsible for the COVID-19 pandemic, has been
associated with substantial global morbidity and mortality. Despite a tropism that is largely …
associated with substantial global morbidity and mortality. Despite a tropism that is largely …
The human genetic epidemiology of COVID-19
Human genetics can inform the biology and epidemiology of coronavirus disease 2019
(COVID-19) by pinpointing causal mechanisms that explain why some individuals become …
(COVID-19) by pinpointing causal mechanisms that explain why some individuals become …
Inborn errors of OAS–RNase L in SARS-CoV-2–related multisystem inflammatory syndrome in children
Multisystem inflammatory syndrome in children (MIS-C) is a rare and severe condition that
follows benign COVID-19. We report autosomal recessive deficiencies of OAS1, OAS2, or …
follows benign COVID-19. We report autosomal recessive deficiencies of OAS1, OAS2, or …
Evolution of enhanced innate immune suppression by SARS-CoV-2 Omicron subvariants
AK Reuschl, LG Thorne, MVX Whelan… - Nature …, 2024 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) human adaptation resulted
in distinct lineages with enhanced transmissibility called variants of concern (VOCs) …
in distinct lineages with enhanced transmissibility called variants of concern (VOCs) …
Genetic regulation of OAS1 nonsense-mediated decay underlies association with COVID-19 hospitalization in patients of European and African ancestries
Abstract The chr12q24. 13 locus encoding OAS1–OAS3 antiviral proteins has been
associated with coronavirus disease 2019 (COVID-19) susceptibility. Here, we report …
associated with coronavirus disease 2019 (COVID-19) susceptibility. Here, we report …
SARS-CoV-2 and innate immunity: the good, the bad, and the “goldilocks”
BL Sievers, MTK Cheng, K Csiba, B Meng… - Cellular & Molecular …, 2024 - nature.com
An ancient conflict between hosts and pathogens has driven the innate and adaptive arms of
immunity. Knowledge about this interplay can not only help us identify biological …
immunity. Knowledge about this interplay can not only help us identify biological …
Risk factors of severe COVID-19: a review of host, viral and environmental factors
The clinical course and outcome of COVID-19 are highly variable, ranging from
asymptomatic infections to severe disease and death. Understanding the risk factors of …
asymptomatic infections to severe disease and death. Understanding the risk factors of …
Multi-ancestry fine mapping implicates OAS1 splicing in risk of severe COVID-19
Abstract The OAS1/2/3 cluster has been identified as a risk locus for severe COVID-19
among individuals of European ancestry, with a protective haplotype of approximately 75 …
among individuals of European ancestry, with a protective haplotype of approximately 75 …
PLSCR1 is a cell-autonomous defence factor against SARS-CoV-2 infection
Understanding protective immunity to COVID-19 facilitates preparedness for future
pandemics and combats new SARS-CoV-2 variants emerging in the human population …
pandemics and combats new SARS-CoV-2 variants emerging in the human population …
Interferon induction, evasion, and paradoxical roles during SARS‐CoV‐2 infection
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), the causative agent of
coronavirus disease 2019 (COVID‐19), has caused millions of deaths in the past two years …
coronavirus disease 2019 (COVID‐19), has caused millions of deaths in the past two years …