Age-related macular degeneration (AMD) is the leading cause of blindness among the
elderly. Dry AMD has unclear etiology and no treatment. Lipid-rich drusen are the hallmark …

A primary pathological defect in the heritable eye disorder Stargardt disease is excessive
accumulation of cytotoxic lipofuscin bisretinoids in the retina. Age-dependent accumulation …

Background: How signals from activated angiotensin type-2 receptors (AT2R) mediate
inhibition of sodium ion (Na+) reabsorption in renal proximal tubule cells is currently …

Deactivation of G-protein-coupled receptors (GPCRs) involves multiple phosphorylations
followed by arrestin binding, which uncouples the GPCR from G-protein activation. Some …

In the vertebrate retina, phosphorylation of photoactivated visual pigments in rods and cones
by G protein–coupled receptor kinases (GRKs) is essential for sustained visual function …

The retina is famous for its ability to operate under a broad range of light intensities. This is
partly due to the presence of two types of photoreceptor cells, rods and cones. Rods are …

Timely recovery of the light response in photoreceptors requires efficient inactivation of
photoactivated rhodopsin. This process is initiated by phosphorylation of its carboxyl …

Purpose: Light detection in retinal rod photoreceptors is initiated by activation of the visual
pigment rhodopsin. A critical, yet often-overlooked, step enabling efficient perception of light …

Rhodopsin is the critical receptor molecule which enables vertebrate rod photoreceptor cells
to detect a single photon of light and initiate a cascade of molecular events leading to visual …

Lipid rafts are localized liquid-ordered regions of the plasma membrane that contain high
levels of cholesterol and glycosphingolipids, and are resistant to extraction with nonionic …