Treatment of acute uncomplicated appendicitis

DA Talan, S Di Saverio - New England Journal of Medicine, 2021 - Mass Medical Soc
Key Clinical Points Treatment of Acute Uncomplicated Appendicitis Patients with acute,
localized, uncomplicated appendicitis (approximately 80% of all appendicitis cases) are …

Burden and cost of gastrointestinal, liver, and pancreatic diseases in the United States: update 2021

AF Peery, SD Crockett, CC Murphy, ET Jensen, HP Kim… - Gastroenterology, 2022 - Elsevier
Background & Aims Gastrointestinal diseases account for considerable health care use and
expenditures. We estimated the annual burden, costs, and research funding associated with …

Diagnosis and treatment of appendicitis: systematic review and meta-analysis

R Lamm, SS Kumar, AT Collings, IN Haskins… - Surgical …, 2023 - Springer
Background The optimal diagnosis and treatment of appendicitis remains controversial. This
systematic review details the evidence and current best practices for the evaluation and …

Effect of oral moxifloxacin vs intravenous ertapenem plus oral levofloxacin for treatment of uncomplicated acute appendicitis: the APPAC II randomized clinical trial

S Sippola, J Haijanen, J Grönroos, T Rautio… - Jama, 2021 - jamanetwork.com
Importance Antibiotics are an effective and safe alternative to appendectomy for managing
uncomplicated acute appendicitis, but the optimal antibiotic regimen is not known. Objective …

Patient factors associated with appendectomy within 30 days of initiating antibiotic treatment for appendicitis

C Parsons, NI Shapiro, R Cooper, A Tichter… - JAMA …, 2022 - jamanetwork.com
Importance Use of antibiotics for the treatment of appendicitis is safe and has been found to
be noninferior to appendectomy based on self-reported health status at 30 days. Identifying …

Antibiotics versus placebo in adults with CT-confirmed uncomplicated acute appendicitis (APPAC III): randomized double-blind superiority trial

P Salminen, S Sippola, J Haijanen… - British Journal of …, 2022 - academic.oup.com
Background Non-operative management of uncomplicated acute appendicitis is an option,
but omission of antibiotics from the regimen has not been tested. Methods A double-blind …

The Great Gut Mimicker: A case report of MIS-C and appendicitis clinical presentation overlap in a teenage patient

M Hwang, K Wilson, L Wendt, J Pohlman, E Densmore… - BMC pediatrics, 2021 - Springer
Background Abdominal pain and other gastrointestinal symptoms are common presenting
features of multisystem inflammatory syndrome in children (MIS-C) and can overlap with …

Appendicectomy versus antibiotics for acute uncomplicated appendicitis in children: an open-label, international, multicentre, randomised, non-inferiority trial

SD St Peter, JR Noel-MacDonnell, NJ Hall, S Eaton… - The Lancet, 2025 - thelancet.com
Background Support for the treatment of uncomplicated appendicitis with non-operative
management rather than surgery has been increasing in the literature. We aimed to …

[HTML][HTML] Patient experience or patient satisfaction? A systematic review of child-and family-reported experience measures in pediatric surgery

J Ferreira, P Patel, E Guadagno, N Ow, J Wray… - Journal of Pediatric …, 2023 - Elsevier
Purpose Patient-reported outcome measures (PROMs) and patient-reported experience
measures (PREMs) are increasingly recognized as important health care quality indicators …

The role of a pediatric tertiary care center in avoiding collateral damage for children with acute appendicitis during the COVID-19 outbreak

L Montalva, A Haffreingue, L Ali, S Clariot… - Pediatric Surgery …, 2020 - Springer
Purpose To evaluate the impact of the COVID-19 pandemic-related lockdown on
management and outcomes of children with acute appendicitis. Methods A retrospective …