BACKGROUND Recurrent miscarriage and pre-eclampsia are common reproductive
disorders, but their causes are often unknown. Recent evidence has provided new insight …

Proteins encoded by the classical major histocompatibility complex (MHC) genes incite the
vertebrate adaptive immune response by presenting peptide antigens on the cell surface …

The central goal of regenerative medicine is to replace damaged or diseased tissue with
cells that integrate and function optimally. The capacity of pluripotent stem cells to produce …

T regulatory (Treg) cells are implicated in maternal immune tolerance of the conceptus at
implantation; however, the antigenic and regulatory signals controlling Treg cells in early …

In the highly derived syngnathid fishes (pipefishes, seadragons & seahorses), the evolution
of sex-role reversed brooding behavior culminated in the seahorse lineage's male …

Seminal fluid is often viewed as simply a vehicle to carry sperm to fertilize the oocyte, but a
more complex function in influencing female reproductive physiology is now evident …

T regulatory (Treg) cells are essential mediators of the maternal immune adaptation
necessary for embryo implantation. In mice, insufficient Treg cell activity results in …

Pre-eclampsia, a common complication of first pregnancies, is thought to result from a poorly
perfused placenta and may reflect an abnormal maternal immune reaction to the …

The events that generate T cell-mediated immune tolerance in early pregnancy are ill-
defined. To investigate the significance of seminal fluid Ags in activating maternal T cells …

Human reproductive failure may be a consequence of aberrant expression of immunological
factors during pregnancy. Although the relative importance of immunological factors in …