State-of-the-Art-Review: mechanisms of action of SGLT2 inhibitors and clinical implications
V Vallon - American Journal of Hypertension, 2024 - academic.oup.com
BACKGROUND Inhibitors of the Na+-coupled glucose transporter SGLT2 (SGLT2i) primarily
shift the reabsorption of large amounts of glucose from the kidney's early proximal tubule to …
shift the reabsorption of large amounts of glucose from the kidney's early proximal tubule to …
New functions and roles of the Na+-H+-exchanger NHE3
JA Dominguez Rieg, T Rieg - Pflügers Archiv-European Journal of …, 2024 - Springer
The sodium/proton exchanger isoform 3 (NHE3) is expressed in the intestine and the kidney,
where it contributes to hydrogen secretion and sodium (re) absorption. The roles of this …
where it contributes to hydrogen secretion and sodium (re) absorption. The roles of this …
Efficacy and safety of dapagliflozin in patients with acute heart failure
ZL Cox, SP Collins, GA Hernandez, AT McRae III… - Journal of the American …, 2024 - jacc.org
Background The primary goals during acute heart failure (AHF) hospitalization are
decongestion and guideline-directed medical therapy (GDMT) optimization. Unlike diuretics …
decongestion and guideline-directed medical therapy (GDMT) optimization. Unlike diuretics …
Mechanisms of heart failure and chronic kidney disease protection by SGLT2 inhibitors in nondiabetic conditions
ACC Girardi, JZ Polidoro, PC Castro… - … of Physiology-Cell …, 2024 - journals.physiology.org
Sodium-glucose cotransporter 2 inhibitors (SGLT2is), initially developed for type 2 diabetes
(T2D) treatment, have demonstrated significant cardiovascular and renal benefits in heart …
(T2D) treatment, have demonstrated significant cardiovascular and renal benefits in heart …
Potassium-alkali–enriched diet, hypertension, and proteinuria following uninephrectomy
DL Ralph, D Ha, H Lei, TS Priver… - Journal of the …, 2024 - journals.lww.com
Background: Losing or donating a kidney is associated with risks of developing
hypertension and albuminuria. Few studies address mechanisms or interventions. We …
hypertension and albuminuria. Few studies address mechanisms or interventions. We …
Managing heart failure in chronic kidney disease: A review of current literature
B Lidgard, N Bansal - Current Treatment Options in Cardiovascular …, 2024 - Springer
Abstract Purpose of Review The purpose of this review was to discuss recent literature
pertaining to the management of heart failure (HF) in patients with chronic kidney disease …
pertaining to the management of heart failure (HF) in patients with chronic kidney disease …
Proximal versus distal diuretics in congestive heart failure
Volume overload represents a hallmark clinical feature linked to the development and
progression of heart failure (HF). Alleviating signs and symptoms of volume overload …
progression of heart failure (HF). Alleviating signs and symptoms of volume overload …
How can inhibition of glucose and sodium transport in the early proximal tubule protect the cardiorenal system?
V Vallon - Nephrology Dialysis Transplantation, 2024 - academic.oup.com
What mechanisms can link the inhibition of sodium-glucose cotransporter 2 (SGLT2) in the
early proximal tubule to kidney and heart protection in patients with and without type 2 …
early proximal tubule to kidney and heart protection in patients with and without type 2 …
Risk of Nephrolithiasis Associated With SGLT2 Inhibitors Versus DPP4 Inhibitors Among Patients With Type 2 Diabetes: A Target Trial Emulation Study
A Shin, JY Shin, EH Kang - Diabetes Care, 2024 - diabetesjournals.org
OBJECTIVE We aim to compare the risk of nephrolithiasis among type 2 diabetes patients
who initiated sodium-glucose cotransporter-2 inhibitors (SGLT2is) versus dipeptidyl …
who initiated sodium-glucose cotransporter-2 inhibitors (SGLT2is) versus dipeptidyl …
Renal upregulation of NCC counteracts empagliflozin-mediated NHE3 inhibition in normotensive but not in hypertensive male rat
PC Castro, TM Santos-Rios… - … of Physiology-Cell …, 2024 - journals.physiology.org
Sodium-glucose cotransporter-2 inhibitors (SGLT2i) reduce blood pressure (BP) in patients
with hypertension, yet the precise molecular mechanisms remain elusive. SGLT2i inhibits …
with hypertension, yet the precise molecular mechanisms remain elusive. SGLT2i inhibits …