Ever present hurdles for the discovery of new drugs for cancer therapy have necessitated
the development of the alternative strategy of drug repurposing, the development of old …

Abstract The Hippo–YAP (Yes-associated protein) pathway is an evolutionarily and
functionally conserved regulator of organ size and growth with crucial roles in cell …

Cancer is a serious health issue in the world due to a large body of cancer-related human
deaths, and there is no current treatment available to efficiently treat the disease as the …

Krüppel‐like factor 5 (KLF5) is a member of the KLF family. Recent studies have suggested
that KLF5 regulates the expression of a large number of new target genes and participates …

YAP1 is one of the most important effectors of the Hippo pathway and has crosstalk with
other cancer promoting pathways. YAP1 contributes to cancer development in various ways …

Curcumin (CCM) is a well-known phytocompound and food component found in the spice
turmeric and has multifunctional bioactivities. However, few studies have examined its …

Imbalances in bone formation and resorption cause osteoporosis. Mounting evidence
supports that brain-derived neurotrophic factor (BDNF) implicates in this process. 7, 8 …

Urological cancers include bladder, prostate and renal cancers that can cause death in
males and females. Patients with urological cancers are mainly diagnosed at an advanced …

The Hippo pathway, initially identified through screenings for mutant tumor suppressors in
Drosophila, is an evolutionarily conserved signaling pathway that controls organ size by …

Despite the development of cancer therapies, the success of most treatments has been
impeded by drug resistance. The crucial role of tumor cell plasticity has emerged recently in …