Structural basis of potential inhibitors targeting SARS-CoV-2 main protease

HM Mengist, T Dilnessa, T Jin - Frontiers in Chemistry, 2021 - frontiersin.org
The Coronavirus disease-19 (COVID-19) pandemic is still devastating the world causing
significant social, economic, and political chaos. Corresponding to the absence of globally …

Pharmacokinetics and biological activity of cucurbitacins

EE Delgado-Tiburcio, J Cadena-Iñiguez… - Pharmaceuticals, 2022 - mdpi.com
Cucurbitacins are a class of secondary metabolites initially isolated from the Cucurbitaceae
family. They are important for their analgesic, anti-inflammatory, antimicrobial, antiviral, and …

[HTML][HTML] Drug repurposing for SARS-CoV-2 main protease: Molecular docking and molecular dynamics investigations

SE Omer, TM Ibrahim, OA Krar, AM Ali, AA Makki… - … and biophysics reports, 2022 - Elsevier
The current novel corona virus illness (COVID-19) is a developing viral disease that was
discovered in 2019. There is currently no viable therapeutic strategy for this illness …

Screening S protein–ACE2 blockers from natural products: strategies and advances in the discovery of potential inhibitors of COVID-19

H Liu, X Liu, X Yuan, C Xu, F Wang, J Lin, R Xu… - European Journal of …, 2021 - Elsevier
Abstract The Coronavirus disease, 2019 (COVID-19) is caused by severe acute respiratory
syndrome Coronavirus 2 (SARS-CoV-2), which poses a major threat to human life and …

Recent Advances in the Application of Cucurbitacins as Anticancer Agents

B Zieniuk, M Pawełkowicz - Metabolites, 2023 - mdpi.com
Cucurbitacins are tetracyclic triterpenoid secondary metabolites, widely distributed in the
Cucurbitaceae family. These bitter-tasting compounds act primarily as defense mechanisms …

Apoptotic and antimetastatic effect of cucurbitacins in cancer: Recent trends and advancement

A Kumar, B Sharma, U Sharma, G Parashar… - Naunyn-Schmiedeberg's …, 2023 - Springer
The Cucurbitaceae family produces a class of secondary metabolites known as
cucurbitacins. The eight cucurbitacin subunits are cucurbitacin B, D, E, I, IIa, L glucoside, Q …

Cucurbitacins as Potent Chemo-Preventive Agents: Mechanistic Insight and Recent Trends

HS Tuli, P Rath, A Chauhan, A Ranjan, S Ramniwas… - Biomolecules, 2022 - mdpi.com
Cucurbitacins constitute a group of cucumber-derived dietary lipids, highly oxidized
tetracyclic triterpenoids, with potential medical uses. These compounds are known to …

Comparative study of the interaction of ivermectin with proteins of interest associated with SARS-CoV-2: A computational and biophysical approach

L González-Paz, ML Hurtado-León, C Lossada… - Biophysical …, 2021 - Elsevier
The SARS-CoV-2 pandemic has accelerated the study of existing drugs. The mixture of
homologs called ivermectin (avermectin-B1a [HB1a]+ avermectin-B1b [HB1b]) has shown …

Molecular docking approach of natural compound from herbal medicine in java against severe acute respiratory syndrome coronavirus-2 receptor

Y Yueniwati, MFR Syaban, IFD Faratisha… - … Macedonian Journal of …, 2021 - oamjms.eu
Indonesia's diversity of natural resources presents an intriguing opportunity for the
exploration of potential herbal medicines. Numerous compounds, both purified and crude …

Butein as a potential binder of human ACE2 receptor for interfering with SARS-CoV-2 entry: A computer-aided analysis

N Kapoor, SM Ghorai, PK Khuswaha… - Journal of Molecular …, 2022 - Springer
Natural products have been included in our dietary supplements and have been shown to
have numerous therapeutic properties. With the looming danger of many zoonotic agents …