Metabolic engineering aims to improve the production of economically valuable molecules
through the genetic manipulation of microbial metabolism. While the discipline is a little over …

Recombinant protein production emerged in the early 1980s with the development of
genetic engineering tools, which represented a compelling alternative to protein extraction …

The optimization of engineered metabolic pathways requires careful control over the levels
and timing of metabolic enzyme expression,,,. Optogenetic tools are ideal for achieving such …

Microbial biosynthesis of plant natural products from simple building blocks is a promising
approach toward scalable production and modification of high-value compounds. The …

A variety of techniques for strain engineering in Saccharomyces cerevisiae have recently
been developed. However, especially when multiple genetic manipulations are required …

Cells can be programmed to monitor and react to their environment using genetic circuits.
Design automation software maps a desired circuit function to a DNA sequence, a process …

The genome of the yeast Saccharomyces cerevisiae has been completely sequenced
through a worldwide collaboration. The sequence of 12,068 kilobases defines 5885 …

Although many cellular and organismal changes have been described in aging individuals,
a precise, molecular cause of aging has yet to be found. A prior study of aging yeast mother …

Ergosterol (ERG) is a critical sterol in the cell membranes of fungi, and its biosynthesis is
tightly regulated by 25 known enzymes along the ERG production pathway. The effects of …

Calorie restriction extends life-span in a wide variety of organisms. Although it has been
suggested that calorie restriction may work by reducing the levels of reactive oxygen species …