Membrane fusion is an essential step when enveloped viruses enter cells. Lipid bilayer
fusion requires catalysis to overcome a high kinetic barrier; viral fusion proteins are the …

Dengue virus (DENV) is a mosquito-borne Flavivirus that is endemic in many tropical and
sub-tropical countries where the transmission vectors Aedes spp. mosquitoes resides. There …

Dengue is the most prevalent arthropod-borne viral disease, caused by dengue virus, a
member of the Flaviviridae family. Its worldwide incidence is now a major health problem …

Abstract Dengue, Japanese encephalitis, West Nile and yellow fever belong to the Flavivirus
genus, which is a member of the Flaviviridae family. They are human pathogens that cause …

Regulated by pH, membrane-anchored proteins E and M function during dengue virus
maturation and membrane fusion. Our atomic model of the whole virion from cryo–electron …

Infection by viruses having lipid-bilayer envelopes proceeds through fusion of the viral
membrane with a membrane of the target cell. Viral'fusion proteins' facilitate this process …

Dengue virus enters a host cell when the viral envelope glycoprotein, E, binds to a receptor
and responds by conformational rearrangement to the reduced pH of an endosome. The …

Zika virus (ZIKV) is an enveloped, icosahedral flavivirus that has structural and functional
similarities to other human flavivirus pathogens such as dengue (DENV), West Nile (WNV) …

Abstract Dengue virus (DENV 1-4) represents a major emerging arthropod-borne pathogen.
All four DENV serotypes are prevalent in the (sub) tropical regions of the world and infect 50 …

The quest for an effective dengue vaccine has culminated in two approved vaccines and
another that has completed phase 3 clinical trials. However, shortcomings exist in each …