In many mammalian species, the accessory olfactory system plays a central role in guiding
behavioral and physiological responses to social and reproductive interactions. Because of …

G protein–coupled receptor (GPCR) signaling is ubiquitous. As an archetype of this
signaling motif, rod phototransduction has provided many fundamental, quantitative details …

Mammalian odorant receptors are a diverse and rapidly evolving set of G protein-coupled
receptors expressed in olfactory cilia membranes. Most odorant receptors show little to no …

The molecular basis for odor perception in humans remains enigmatic because of the
difficulty in studying odorant receptors (ORs) outside their native environment. Efforts toward …

Vertebrate animals detect odors through olfactory receptors (ORs), members of the G protein-
coupled receptor (GPCR) family. Due to the difficulty in the heterologous expression of ORs …

Olfactory receptors (ORs) belong to class A G-protein coupled receptors (GPCRs) and are
activated by a variety of odorants. To date, there is no three-dimensional structure of an OR …

Odorant receptors (ORs) expressed in mammalian olfactory sensory neurons are essential
for the sense of smell. However, structure–function studies of many ORs are hampered by …

The highly individual plasma membrane expression and cAMP signaling of odorant
receptors have hampered their ligand assignment and functional characterization in test cell …

It is widely accepted that the SARS-CoV-2 betacoronavirus infects humans through binding
the human Angiotensin Receptor 2 (ACE2) that lines the nasal cavity and lungs, followed by …

Many G-protein coupled receptors (GPCRs), such as odorant receptors (ORs), cannot be
characterized in heterologous cells because of their difficulty in trafficking to the plasma …