Effect of the microenvironment on mesenchymal stem cell paracrine signaling: opportunities to engineer the therapeutic effect

GD Kusuma, J Carthew, R Lim… - Stem cells and …, 2017 - liebertpub.com
Cues from the extracellular environment, including physical stimuli, are well known to affect
mesenchymal stem cell (MSC) properties in terms of proliferation and differentiation. Many …

Paracrine mechanisms of mesenchymal stem cells in tissue repair

M Gnecchi, P Danieli, G Malpasso… - Mesenchymal Stem Cells …, 2016 - Springer
Tissue regeneration from transplanted mesenchymal stromal cells (MSC) either through
transdifferentiation or cell fusion was originally proposed as the principal mechanism …

[HTML][HTML] The stem cell secretome and its role in brain repair

D Drago, C Cossetti, N Iraci, E Gaude, G Musco… - Biochimie, 2013 - Elsevier
Compelling evidence exists that non-haematopoietic stem cells, including mesenchymal
(MSCs) and neural/progenitor stem cells (NPCs), exert a substantial beneficial and …

Proteomic techniques for characterisation of mesenchymal stem cell secretome

HK Skalnikova - Biochimie, 2013 - Elsevier
Mesenchymal stem cells (MSCs) are multipotent cells with a substantial potential in human
regenerative medicine due to their ability to migrate to sites of injury, capability to suppress …

Effect of the biodegradation rate controlled by pore structures in magnesium phosphate ceramic scaffolds on bone tissue regeneration in vivo

JA Kim, J Lim, R Naren, H Yun, EK Park - Acta biomaterialia, 2016 - Elsevier
Similar to calcium phosphates, magnesium phosphate (MgP) ceramics have been shown to
be biocompatible and support favorable conditions for bone cells. Micropores below 25 μm …

Mapping of the secretome of primary isolates of mammalian cells, stem cells and derived cell lines

H Skalnikova, J Motlik, SJ Gadher, H Kovarova - Proteomics, 2011 - Wiley Online Library
Within a mammalian organism, the interaction among cells both at short and long distances
is mediated by soluble factors released by cells into the extracellular environment. The …

Stem cells: insights into the secretome

M Makridakis, MG Roubelakis, A Vlahou - Biochimica et Biophysica Acta …, 2013 - Elsevier
Stem cells have been considered as possible therapeutic vehicles for different health related
problems such as cardiovascular and neurodegenerative diseases and cancer. Secreted …

Multistage genome-wide association meta-analyses identified two new loci for bone mineral density

L Zhang, HJ Choi, K Estrada, PJ Leo, J Li… - Human molecular …, 2014 - academic.oup.com
Aiming to identify novel genetic variants and to confirm previously identified genetic variants
associated with bone mineral density (BMD), we conducted a three-stage genome-wide …

Differential secretome analysis of cancer‐associated fibroblasts and bone marrow‐derived precursors to identify microenvironmental regulators of colon cancer …

A De Boeck, A Hendrix, D Maynard… - …, 2013 - Wiley Online Library
The identification of cancer‐associated fibroblast (CAF)‐derived proteins that mediate
interactions between the tumor stroma and cancer cells is a crucial step toward the …

Cell surface markers for mesenchymal stem cells related to the skeletal system: A scoping review

LN Fonseca, S Bolívar-Moná, T Agudelo, LD Beltrán… - Heliyon, 2023 - cell.com
Multipotent mesenchymal stromal cells (MSCs) have been described as bone marrow
stromal cells, which can form cartilage, bone or hematopoietic supportive stroma. In 2006 …