Host cytosolic sensing of Mycobacterium tuberculosis (M. tuberculosis) RNA by the RIG-I–
like receptor (RLR) family perturbs innate immune control within macrophages; however, a …

ISG15 encoded by a type I interferon (IFN) inducible gene mediates an important cellular
process called ISGylation. ISGylation emerges as a powerful host tactic against intracellular …

Although the importance of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA)
sensors in controlling viral infection is well established, their role in promoting an effective …

The bacillus Calmette-Guérin BCG vaccine (Mycobacterium bovis) is primarily used to
prevent tuberculosis (TB) infections but has wide-ranging immunogenic effects. One of its …

Macrophages (MQ) are major constituents of chronically inflamed periapical tissues in apical
periodontitis. This study aimed to investigate the immunomodulatory effect of engineered …

Background Blood transcriptomics can be used for confirmation of tuberculosis diagnosis or
sputumless triage, and a comparison of their practical diagnostic accuracy is needed to …

Pneumonia is a worldwide threat to public health, demanding novel preventative and
therapeutic strategies. The lung epithelium is a critical environmental interface that functions …

In human primary dendritic cells (DC) rapamycin—an autophagy inducer and protein
synthesis inhibitor—overcomes the autophagy block induced by Mycobacterium …

Current search for a new effective vaccine against tuberculosis involves selected antigens,
vectors and adjuvants. These are being evaluated usually by their booster inoculation …

Retinoic acid inducible gene I (Rig-I) is a cytosolic pattern recognition receptor canonically
described for its important role in sensing viral RNAs. Increasingly, bacterially-derived RNA …