The molecular chaperone Hsp90 is one component of a highly complex and interactive
cellular proteostasis network (PN) that participates in protein folding, directs misfolded and …

The molecular chaperones are central mediators of protein homeostasis. In that role, they
engage in widespread protein–protein interactions (PPIs) with each other and with their" …

To discover novel antibacterial agents, a series of novel 1, 3, 4-thiadiazole derivatives
containing an amide moiety were designed and synthesized, and their antibacterial activities …

The microtubule-associated protein tau (MAPT, tau) forms neurotoxic aggregates that
promote cognitive deficits in tauopathies, the most common of which is Alzheimer's disease …

Cells constantly need to adopt to changing environmental conditions, maintaining
homeostasis and proteostasis. Heat shock proteins are a diverse class of molecular …

Background Olaparib, a poly (adenosine diphosphate-ribose) polymerase (PARP) inhibitor
has demonstrated promising efficacy in patients with triple-negative breast cancer (TNBC) …

The transient receptor potential vanilloid 1 (TRPV1) receptor is a nonselective cation
channel, known to be involved in the regulation of many important physiological and …

Previously, vibsanin B (ViB) was found to preferentially target HSP90β compared to
HSP90α. In this study, multiple experiments, including pull-down assays of biotin-ViB with …

Abstract Heat shock protein 90 (HSP90) inhibition has aroused increasing enthusiasm in
antitumor strategies in recent years. According to our previous studies, we synthesized a …

In tumors, Heat shock protein HSP 90-alpha (Hsp90α) maintains the activity of over-
activated or mutated signal transduction proteins and accelerates the malignant …