Fusion of the endoplasmic reticulum by membrane-bound GTPases

J Hu, TA Rapoport - Seminars in cell & developmental biology, 2016 - Elsevier
The endoplasmic reticulum (ER) membrane forms an elaborate network of tubules and
sheets that is continuously remodeled. This dynamic behavior requires membrane fusion …

Cooperation of the ER-shaping proteins atlastin, lunapark, and reticulons to generate a tubular membrane network

S Wang, H Tukachinsky, FB Romano, TA Rapoport - elife, 2016 - elifesciences.org
In higher eukaryotes, the endoplasmic reticulum (ER) contains a network of membrane
tubules, which transitions into sheets during mitosis. Network formation involves curvature …

Diverse role of SNARE protein Sec22 in vesicle trafficking, membrane fusion, and autophagy

M Adnan, W Islam, J Zhang, W Zheng, GD Lu - Cells, 2019 - mdpi.com
Protein synthesis begins at free ribosomes or ribosomes attached with the endoplasmic
reticulum (ER). Newly synthesized proteins are transported to the plasma membrane for …

Human atlastins are sufficient to drive the fusion of liposomes with a physiological lipid composition

E Jang, Y Moon, SY Yoon, JAR Diaz, M Lee… - Journal of Cell …, 2023 - rupress.org
The dynamin-like GTPase atlastin is believed to be the minimal machinery required for
homotypic endoplasmic reticulum (ER) membrane fusion, mainly because Drosophila …

Assembly-hub function of ER-localized SNARE proteins in biogenesis of tombusvirus replication compartment

Z Sasvari, N Kovalev, PA Gonzalez, K Xu… - PLoS …, 2018 - journals.plos.org
Positive-strand RNA viruses assemble numerous membrane-bound viral replicase
complexes within large replication compartments to support their replication in infected cells …

Sec22b is a critical and nonredundant regulator of plasma cell maintenance

A Bonaud, L Gargowitsch, SM Gilbert… - Proceedings of the …, 2023 - National Acad Sciences
Despite the essential role of plasma cells in health and disease, the cellular mechanisms
controlling their survival and secretory capacity are still poorly understood. Here, we …

The intramembrane protease SPP impacts morphology of the endoplasmic reticulum by triggering degradation of morphogenic proteins

D Avci, NS Malchus, R Heidasch, H Lorenz… - Journal of Biological …, 2019 - ASBMB
The endoplasmic reticulum (ER), as a multifunctional organelle, plays crucial roles in lipid
biosynthesis and calcium homeostasis as well as the synthesis and folding of secretory and …

Apelin as a new therapeutic target for COVID-19 treatment

J Park, MY Park, Y Kim, Y Jun, U Lee… - QJM: An International …, 2023 - academic.oup.com
Background Apelin is an endogenous neuropeptide that binds to the G-protein-coupled
receptor (APJ) and participates in a variety of physiological processes in the heart, lungs …

Physiological lipid composition is vital for homotypic ER membrane fusion mediated by the dynamin-related GTPase Sey1p

S Sugiura, J Mima - Scientific Reports, 2016 - nature.com
Homotypic fusion of the endoplasmic reticulum (ER) is required for generating and
maintaining the characteristic reticular ER membrane structures. This organelle membrane …

The dynamin-like GTPase FgSey1 plays a critical role in fungal development and virulence in Fusarium graminearum

X Chong, C Wang, Y Wang, Y Wang… - Applied and …, 2020 - Am Soc Microbiol
Fusarium graminearum, the main pathogenic fungus causing Fusarium head blight (FHB),
produces deoxynivalenol (DON), a key virulence factor, which is synthesized in the …