Small GTPases use GDP/GTP alternation to actuate a variety of functional switches that are
pivotal for cell dynamics. The GTPase switch is turned on by GEFs, which stimulate …

Animal models have historically played a critical role in the exploration and characterization
of disease pathophysiology and target identification and in the evaluation of novel …

Cell migration affects all morphogenetic processes and contributes to numerous diseases,
including cancer and cardiovascular disease. For most cells in most environments …

Cell migration requires sustained forward movement of the plasma membrane at the cell's
front or" leading edge." To date, researchers have uncovered four distinct ways of extending …

The phagocytic clearance of dying cells in a tissue is a highly orchestrated series of
intercellular events coordinated by a complex signaling network. Recent data from genetic …

To maintain organismal homeostasis, phagocytes engulf dead cells, which are recognized
as dead by virtue of a characteristic" eat me" signal exposed on their surface. The dead cells …

Capping protein (CP) binds the fast growing barbed end of the actin filament and regulates
actin assembly by blocking the addition and loss of actin subunits. Recent studies provide …

Rho GTPases represent a family of small GTP-binding proteins involved in cell cytoskeleton
organization, migration, transcription, and proliferation. A common theme of these processes …

This paper synthesizes recent progress toward understanding the integrated control systems
and fail-safes that guide the quality and quantity of antibody produced by B cells. We focus …

Neurotrophic factors play key roles in the development and survival of neurons. The potent
neuroprotective effects of neurotrophic factors, including brain-derived neurotrophic factor …