A higher incidence of colorectal cancer (CRC) is found in males compared to females.
Young women (18–44 years) with CRC have a better survival outcome compared to men of …

Our understanding of the intracrine (or local) regulation of estrogen and other steroid
synthesis and degradation expanded in the last decades, also thanks to recent …

Purpose Ten eleven translocation (TET) enzyme activity is essential for active DNA
demethylation in biological processes, and their altered expression has been observed in …

The extragonadal synthesis of biological active steroid hormones from their inactive
precursors in target tissues is named “intracrinology.” Of particular importance for the …

Hypoxic conditions during the formation of colorectal cancer may support the development
of more aggressive tumors. Hypoxia-inducible factor (HIF) is a heterodimeric complex …

Abstract 17β‐hydroxysteroid dehydrogenase (17β‐HSD10) is a multifunctional human
enzyme with important roles both as a structural component and also as a catalyst of many …

According to recent statistics, Lung Cancer (LC) is one of the most frequently diagnosed
tumor types, representing nearly 12% of all global cancer cases. Moreover, in recent years …

During pregnancy, the adaptive changes in uterine circulation and the formation of the
placenta are essential for the growth of the fetus and the well‐being of the mother. The …

Background Colorectal cancer (CRC) is one of the most common and comprehensively
studied malignancies. Hypoxic conditions during formation of CRC may support the …

Irinotecan (CPT11) is widely prescribed for treatment of various intractable cancers such as
advanced and metastatic colon cancer cells, but its continuous treatment promotes the …