G Konings, L Brentjens, B Delvoux… - Frontiers in …, 2018 - frontiersin.org
Our understanding of the intracrine (or local) regulation of estrogen and other steroid synthesis and degradation expanded in the last decades, also thanks to recent …
Purpose Ten eleven translocation (TET) enzyme activity is essential for active DNA demethylation in biological processes, and their altered expression has been observed in …
L Secky, M Svoboda, L Klameth, E Bajna… - Journal of drug …, 2013 - Wiley Online Library
The extragonadal synthesis of biological active steroid hormones from their inactive precursors in target tissues is named “intracrinology.” Of particular importance for the …
Hypoxic conditions during the formation of colorectal cancer may support the development of more aggressive tumors. Hypoxia-inducible factor (HIF) is a heterodimeric complex …
L Vinklarova, M Schmidt, O Benek… - Journal of …, 2020 - Wiley Online Library
Abstract 17β‐hydroxysteroid dehydrogenase (17β‐HSD10) is a multifunctional human enzyme with important roles both as a structural component and also as a catalyst of many …
BK Słowikowski, M Jankowski… - Biomedicine & …, 2021 - Elsevier
According to recent statistics, Lung Cancer (LC) is one of the most frequently diagnosed tumor types, representing nearly 12% of all global cancer cases. Moreover, in recent years …
XQ Hu, R Song, L Zhang - Oxidative Medicine and Cellular …, 2019 - Wiley Online Library
During pregnancy, the adaptive changes in uterine circulation and the formation of the placenta are essential for the growth of the fetus and the well‐being of the mother. The …
AA Rawluszko, KE Bujnicka, K Horbacka, P Krokowicz… - BMC cancer, 2013 - Springer
Background Colorectal cancer (CRC) is one of the most common and comprehensively studied malignancies. Hypoxic conditions during formation of CRC may support the …
T Matsunaga, N Okumura, H Saito, Y Morikawa… - Chemico-Biological …, 2020 - Elsevier
Irinotecan (CPT11) is widely prescribed for treatment of various intractable cancers such as advanced and metastatic colon cancer cells, but its continuous treatment promotes the …