Platelet-derived growth factors (PDGFs) and PDGF receptors (PDGFRs) are expressed in a
variety of tumors. Activation of the PDGF/PDGFR signaling pathway is associated with …

Metastasis has long been understood to lead to the overwhelming majority of cancer-related
deaths. However, our understanding of the metastatic process, and thus our ability to …

Pericytes are a type of mural cell located between the endothelial cells of capillaries and the
basement membrane, which function to regulate the capillary vasomotor and maintain …

Brain cancers carry bleak prognoses, with therapeutic advances helping only a minority of
patients over the past decade. The brain tumour microenvironment (TME) is highly …

Breast cancer is the most commonly diagnosed cancer in the USA. Although advances in
treatment over the past several decades have significantly improved the outlook for this …

As one of the most significant imaging modalities currently available, magnetic resonance
imaging (MRI) has been extensively utilized for clinically accurate cancer diagnosis …

Platelet-derived growth factor receptor A (PDGFRA) mutations occur in approximately 10–
15% of gastrointestinal stromal tumors (GISTs). These tumors with PDGFRA mutations have …

The application of chemodynamic therapy (CDT) for cancer is a serious challenge owing to
the low efficiency of the Fenton catalyst and insufficient H2O2 expression in cells. Herein, we …

Tumor biomarkers, the substances which are produced by tumors or the body's responses to
tumors during tumorigenesis and progression, have been demonstrated to possess critical …

The vascular wall is comprised of distinct layers controlling angiogenesis, blood flow, vessel
anchorage within organs, and cell and molecule transit between blood and tissues …