Overactive bladder (OAB) syndrome is a prevalent condition of the lower urinary tract that
causes symptoms, such as urinary frequency, urinary urgency, urge incontinence, and …

Since the first discovery in 1989, the β3-adrenoceptor (β3-AR) has gained great attention
because it showed the ability to regulate many physiologic and metabolic activities, such as …

Rett Syndrome is an X-linked neurodevelopmental disorder (RTT; OMIM# 312750)
associated to MECP2 mutations. MeCP2 dysfunction is seen as one cause for the …

Parasympathetic nerve-mediated contractions of detrusor smooth muscle are generated by
ATP and acetylcholine (ACh) release from efferent nerve terminals. In humans, ACh is …

Introduction Lower urinary tract symptoms (LUTS) due to overactive bladder (OAB) are
caused by spontaneous detrusor contractions. Medical treatment with muscarinic receptor …

Study design A Retrospective study. Objectives To investigate the effects of vibegron on
urodynamic parameters of individuals with spinal cord injury (SCI). Setting The National …

Background: Benign prostatic hyperplasia (BPH) is prevalent among the aging male
population and often presents with distressing lower urinary tract symptoms. There is …

Abstract Rett syndrome (RTT; OMIM# 312750) is mainly caused by mutations in the X-linked
MECP2 gene (methyl-CpG-binding protein 2 gene; OMIM* 300005), which leads to …

Adrenergic receptors of the β3-subtype (β3-ADRs) seem to represent a new target for a
more effective pharmacological treatment of overactive bladder (OAB), a wide spread …

Presynaptic α2-adrenoceptors are localized on axon terminals of many noradrenergic and
non-noradrenergic neurons in the peripheral and central nervous systems. Their activation …