Human papillomavirus molecular biology

ME Harden, K Munger - Mutation Research/Reviews in Mutation Research, 2017 - Elsevier
Human papillomaviruses are small DNA viruses with a tropism for squamous epithelia. A
unique aspect of human papillomavirus molecular biology involves dependence on the …

Clinical implications of (epi) genetic changes in HPV-induced cervical precancerous lesions

RDM Steenbergen, PJF Snijders… - Nature Reviews …, 2014 - nature.com
Infection of cervical epithelium with high-risk human papilloma virus (hrHPV) might result in
productive or transforming cervical intraepithelial neoplasia (CIN) lesions, the morphology of …

Papillomaviruses: Viral evolution, cancer and evolutionary medicine

IG Bravo, M Félez-Sánchez - Evolution, medicine, and public …, 2015 - academic.oup.com
Papillomaviruses (PVs) are a numerous family of small dsDNA viruses infecting virtually all
mammals. PVs cause infections without triggering a strong immune response, and natural …

Pathogenesis of human papillomavirus‐associated mucosal disease

IJ Groves, N Coleman - The Journal of pathology, 2015 - Wiley Online Library
Human papillomaviruses (HPVs) are a necessary cause of carcinoma of the cervix and other
mucosal epithelia. Key events in high‐risk HPV (HRHPV)‐associated neoplastic …

Epigenetic regulation of human papillomavirus transcription in the productive virus life cycle

M Burley, S Roberts, JL Parish - Seminars in immunopathology, 2020 - Springer
Human papillomaviruses (HPV) are a large family of viruses which contain a circular, double-
stranded DNA genome of approximately 8000 base pairs. The viral DNA is chromatinized by …

The role of HPV‑induced epigenetic changes in cervical carcinogenesis

MLR Da Silva, BHDR De Albuquerque… - Biomedical …, 2021 - spandidos-publications.com
Cervical cancer is associated with infection by certain types of human papillomaviruses
(HPVs), and this affects women worldwide. Despite the improvements in prevention and …

Detection of host cell gene/HPV DNA methylation markers: a promising triage approach for cervical cancer

L Zhang, W Tan, H Yang, S Zhang, Y Dai - Frontiers in Oncology, 2022 - frontiersin.org
Cervical cancer is the most prevalent gynecologic malignancy, especially in women of low-
and middle-income countries (LMICs). With a better understanding of the etiology and …

Epigenetic alterations in human papillomavirus-associated cancers

D Soto, C Song, ME McLaughlin-Drubin - Viruses, 2017 - mdpi.com
Approximately 15–20% of human cancers are caused by viruses, including human
papillomaviruses (HPVs). Viruses are obligatory intracellular parasites and encode proteins …

The molecular mechanism of human papillomavirus-induced carcinogenesis in head and neck squamous cell carcinoma

D Sano, N Oridate - International journal of clinical oncology, 2016 - Springer
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer
worldwide. Recently, the incidence of oropharyngeal cancer (OPC) has increased markedly …

The nuclear DNA sensor IFI16 acts as a restriction factor for human papillomavirus replication through epigenetic modifications of the viral promoters

I Lo Cigno, M De Andrea, C Borgogna… - Journal of …, 2015 - Am Soc Microbiol
The human interferon-inducible IFI16 protein, an innate immune sensor of intracellular DNA,
was recently demonstrated to act as a restriction factor for human cytomegalovirus (HCMV) …