Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …

α-synuclein (α-syn) is a protein associated with the pathogenesis of Parkinson's disease
(PD), the second most common neurodegeneration disease with no effective treatment …

The incidence of Alzheimer's disease (AD) is growing every day and finding an effective
treatment is becoming more vital. Amyloid-β (Aβ) has been the focus of research for several …

Transactive response DNA binding protein of 43 kDa (TDP-43) is an intranuclear protein
encoded by the TARDBP gene that is involved in RNA splicing, trafficking, stabilization, and …

The spontaneous assembly of proteins into amyloid fibrils is a phenomenon central to many
increasingly common and currently incurable human disorders, including Alzheimer's and …

Numerous epidemiological studies have shown a significantly higher risk for development of
Alzheimer's disease (AD) in patients affected by type 2 diabetes (T2D), but the molecular …

Protein misfolding and aggregation are known to play a crucial role in a number of important
human diseases (Alzheimer's, Parkinson's, prion, diabetes, cataracts, etc.) as well as in a …

It is well-established that inflammation plays an important role in Alzheimer's disease (AD)
and frontotemporal lobar dementia (FTLD). Inflammation and synapse loss occur in disease …

Genetic, clinical, histopathological and biomarker data strongly support Beta-amyloid (Aβ)
induced spreading of Tau-pathology beyond entorhinal cortex (EC), as a crucial process in …

Amyloid protein aggregation is associated with many neurodegenerative diseases,
including amyloid‐β (Aβ) in Alzheimer disease, human islet amyloid polypeptide (hIAPP) in …