Mitochondrial and metabolic dysfunction in ageing and age-related diseases
Organismal ageing is accompanied by progressive loss of cellular function and systemic
deterioration of multiple tissues, leading to impaired function and increased vulnerability to …
deterioration of multiple tissues, leading to impaired function and increased vulnerability to …
Epigenetic regulation in metabolic diseases: mechanisms and advances in clinical study
YL Wu, ZJ Lin, CC Li, X Lin, SK Shan, B Guo… - … and Targeted Therapy, 2023 - nature.com
Epigenetics regulates gene expression and has been confirmed to play a critical role in a
variety of metabolic diseases, such as diabetes, obesity, non-alcoholic fatty liver disease …
variety of metabolic diseases, such as diabetes, obesity, non-alcoholic fatty liver disease …
Compromised hepatic mitochondrial fatty acid oxidation and reduced markers of mitochondrial turnover in human NAFLD
MP Moore, RP Cunningham, GM Meers… - …, 2022 - Wiley Online Library
Background and Aims NAFLD and its more‐advanced form, steatohepatitis (NASH), is
associated with obesity and is an independent risk factor for cardiovascular, liver‐related …
associated with obesity and is an independent risk factor for cardiovascular, liver‐related …
How does hepatic lipid accumulation lead to lipotoxicity in non-alcoholic fatty liver disease?
Y Geng, KN Faber, VE de Meijer, H Blokzijl… - Hepatology …, 2021 - Springer
Background Non-alcoholic fatty liver disease (NAFLD), characterized as excess lipid
accumulation in the liver which is not due to alcohol use, has emerged as one of the major …
accumulation in the liver which is not due to alcohol use, has emerged as one of the major …
Triggering and resolution of inflammation in NASH
S Schuster, D Cabrera, M Arrese… - Nature reviews …, 2018 - nature.com
Nonalcoholic steatohepatitis (NASH) is considered the progressive form of nonalcoholic fatty
liver disease (NAFLD) and is characterized by liver steatosis, inflammation, hepatocellular …
liver disease (NAFLD) and is characterized by liver steatosis, inflammation, hepatocellular …
Role of oxidative stress in pathophysiology of nonalcoholic fatty liver disease
Liver steatosis without alcohol consumption, namely, nonalcoholic fatty liver disease
(NAFLD), is a common hepatic condition that encompasses a wide spectrum of …
(NAFLD), is a common hepatic condition that encompasses a wide spectrum of …
Genetics and epigenetics of NAFLD and NASH: Clinical impact
Non-alcoholic fatty liver disease (NAFLD) is now recognised as the most common liver
disease worldwide. It encompasses a broad spectrum of conditions, from simple steatosis …
disease worldwide. It encompasses a broad spectrum of conditions, from simple steatosis …
Nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) is a disorder characterized by excess accumulation
of fat in hepatocytes (nonalcoholic fatty liver (NAFL)); in up to 40% of individuals, there are …
of fat in hepatocytes (nonalcoholic fatty liver (NAFL)); in up to 40% of individuals, there are …
Metabolic activation of intrahepatic CD8+ T cells and NKT cells causes nonalcoholic steatohepatitis and liver cancer via cross-talk with hepatocytes
MJ Wolf, A Adili, K Piotrowitz, Z Abdullah, Y Boege… - Cancer cell, 2014 - cell.com
Hepatocellular carcinoma (HCC), the fastest rising cancer in the United States and
increasing in Europe, often occurs with nonalcoholic steatohepatitis (NASH). Mechanisms …
increasing in Europe, often occurs with nonalcoholic steatohepatitis (NASH). Mechanisms …
History of nonalcoholic fatty liver disease
Based on the assumption that characterizing the history of a disease will help in improving
practice while offering a clue to research, this article aims at reviewing the history of …
practice while offering a clue to research, this article aims at reviewing the history of …