Endothelin (ET) peptides and their receptors are intimately involved in the physiological
control of systemic blood pressure and body Na homeostasis, exerting these effects through …

Over two decades of research have demonstrated that the peptide hormone endothelin-1
(ET-1) plays multiple, complex roles in cardiovascular, neural, pulmonary, reproductive, and …

In the kidney nitric oxide (NO) has numerous important functions including the regulation of
renal haemodynamics, maintenance of medullary perfusion, mediation of pressure …

NO plays a role in the regulation of blood pressure through its effects on renal,
cardiovascular, and central nervous system function. It is generally thought to freely diffuse …

The angiotensin II type 1 receptor (AT1R) mediates most hypertensive actions of angiotensin
II. To understand the molecular regulation of the AT1R in normal physiology and …

Several new approaches and provocative findings have emerged over the last year. A
regulatory role for nitric oxide in the control of the renal microcirculation and as a participant …

Since its discovery in 1988 as an endothelial cell-derived peptide that exerts the most potent
vasoconstriction of any known endogenous compound, endothelin (ET) has emerged as an …

Based on the reports reviewed in here, targeting of the renal endothelin system is a possible
therapeutic approach against the development of glomerular injury. More animal and clinical …

NaCl absorption along the nephron is regulated not just by humoral factors but also by
factors that do not circulate or act on the cells where they are produced. Generally, nitric …

Abstract There is a 1–4 mmol/L rise in plasma sodium concentrations in individuals with high
salt intake and in patients with essential hypertension. In this study, we used 3 independent …