▪ Abstract Opioid receptors belong to the large superfamily of seven transmembrane-
spanning (7TM) G protein-coupled receptors (GPCRs). As a class, GPCRs are of …

Cloning of multiple opioid receptors has presented opportunities to investigate the
mechanisms of multiple opioid receptor signaling and the regulation of these signals. The …

THE ORL1 receptor, an orphan receptor whose human1and murine2-8 complementary
DNAs have recently been characterized, structurally resembles opioid receptors and is …

A heptadecapeptide was identified and purified from porcine brain tissue as a ligand for an
orphan heterotrimeric GTP-binding protein (G protein)-coupled receptor (LC132) that is …

It is now clear that opioid receptors participate in the function of the cells of the immune
system, and evidence suggests that opioids modulate both innate and acquired immune …

Opiates like morphine and endogenous opioid peptides exert their pharmacological and
physiological effects through binding to their endogenous receptors, opioid receptors. The …

The isolation of an opioid receptor-related clone soon led to the isolation and
characterization of a new neuropeptide, termed orphanin FQ or nociceptin (OFQ/N). This …

Orphanin FQ (OFQ) is the endogenous agonist of the opioid receptor‐like receptor (ORL‐1).
It and its precursor, prepro‐OFQ, exhibit structural features suggestive of the opioid peptides …

Nociceptin (NC), alias Orphanin FQ, has been recently identified as the endogenous ligand
of the opioid receptor‐like 1 receptor (OP4). This new NC/OP4 receptor system belongs to …

Orphanin FQ (OFQ, Nociceptin) is a recently discovered 17-amino acid neuropeptide that is
structurally related to the opioid peptides but does not bind opioid receptors. OFQ has been …