Collagen hydroxylysine glycosylation: non-conventional substrates for atypical glycosyltransferase enzymes

F De Giorgi, M Fumagalli, L Scietti… - Biochemical Society …, 2021 - portlandpress.com
Collagen is a major constituent of the extracellular matrix (ECM) that confers fundamental
mechanical properties to tissues. To allow proper folding in triple-helices and organization in …

Glycosylation Modulates the Structure and Functions of Collagen: A Review

I Tvaroška - Molecules, 2024 - mdpi.com
Collagens are fundamental constituents of the extracellular matrix and are the most
abundant proteins in mammals. Collagens belong to the family of fibrous or fiber-forming …

Optimized recombinant production of secreted proteins using human embryonic kidney (HEK293) cells grown in suspension

S Faravelli, M Campioni, M Palamini, A Canciani… - Bio …, 2021 - bio-protocol.org
Recombinant proteins are an essential milestone for a plethora of different applications
ranging from pharmaceutical to clinical, and mammalian cell lines are among the currently …

Comparative genomic and crystal structure analyses identify a collagen glucosyltransferase from Acanthamoeba Polyphaga Mimivirus

W Wu, JS Kim, SJ Richards, C Buhlheller, AO Bailey… - bioRxiv, 2022 - biorxiv.org
Abstract Humans and Acanthamoeba Polyphaga Mimivirus share numerous homologous
genes, including collagens and collagen-modifying enzymes. To explore the homology, we …

Full‐Length Human Collagen Lysyl Hydroxylases

L Scietti, F Forneris - Encyclopedia of inorganic and …, 2011 - Wiley Online Library
Procollagen lysyl hydroxylases and glycosyltransferases (LH, also known as procollagen
lysyl‐2‐oxoglutarate dioxygenases (PLOD)) are essential biosynthesis enzymes present in …