Nitric oxide (NO) is an important signaling molecule that is involved in a wide range of
physiological and pathological events in biology. Metal coordination chemistry, especially …

The prevalence of cardiovascular and metabolic disease coupled with kidney dysfunction is
increasing worldwide. This triad of disorders is associated with considerable morbidity and …

Nitric oxide (NO) is a small free radical with critical signaling roles in physiology and
pathophysiology. The generation of sufficient NO levels to regulate the resistance of the …

Intraventricular hemorrhage is one of the most fatal forms of brain injury that is a common
complication of premature infants. However, the therapy of this type of hemorrhage is limited …

In contrast to nitric oxide, which has well established and important roles in the regulation of
blood flow and thrombosis, neurotransmission, the normal functioning of the genitourinary …

During exercise the cardiovascular system has to warrant substrate supply to working
muscle. The main function of red blood cells in exercise is the transport of O2 from the lungs …

Background—Red blood cell transfusion can both benefit and harm. To inform decisions
about transfusion, we aimed to quantify associations of transfusion with clinical outcomes …

Nitrite is one of the players in the broad nitrogen biogeochemical cycle. This nitrogen oxo-
anion is involved in key pathways crucial to life on Earth and to the planetary “recycling” of …

Recent studies have underscored questions about the balance of risk and benefit of RBC
transfusion. A better understanding of the nature and timing of molecular and functional …

Previous studies have revealed a novel interaction between deoxyhemoglobin and nitrite to
generate nitric oxide (NO) in blood. It has been proposed that nitrite acts as an endocrine …