A systematic evaluation of the performance and properties of the UK Biobank Polygenic Risk Score (PRS) Release
DJ Thompson, D Wells, S Selzam, I Peneva, R Moore… - Plos one, 2024 - journals.plos.org
We assess the UK Biobank (UKB) Polygenic Risk Score (PRS) Release, a set of PRSs for 28
diseases and 25 quantitative traits that has been made available on the individuals in UKB …
diseases and 25 quantitative traits that has been made available on the individuals in UKB …
Imputation Server PGS: an automated approach to calculate polygenic risk scores on imputation servers
Polygenic scores (PGS) enable the prediction of genetic predisposition for a wide range of
traits and diseases by calculating the weighted sum of allele dosages for genetic variants …
traits and diseases by calculating the weighted sum of allele dosages for genetic variants …
To weight or not to weight? The effect of selection bias in 3 large electronic health record-linked biobanks and recommendations for practice
Objectives To develop recommendations regarding the use of weights to reduce selection
bias for commonly performed analyses using electronic health record (EHR)-linked biobank …
bias for commonly performed analyses using electronic health record (EHR)-linked biobank …
Uncovering associations between pre-existing conditions and COVID-19 Severity: A polygenic risk score approach across three large biobanks
Objective To overcome the limitations associated with the collection and curation of COVID-
19 outcome data in biobanks, this study proposes the use of polygenic risk scores (PRS) as …
19 outcome data in biobanks, this study proposes the use of polygenic risk scores (PRS) as …
Utility of polygenic scores for differentiating diabetes diagnosis among patients with atypical phenotypes of diabetes
Context Misclassification of diabetes type occurs in people with atypical presentations of
type 1 diabetes (T1D) or type 2 diabetes (T2D). Although current clinical guidelines suggest …
type 1 diabetes (T1D) or type 2 diabetes (T2D). Although current clinical guidelines suggest …
Evaluating the Efficacy of Type 2 Diabetes Polygenic Risk Scores in an Independent European Population
M Brīvība, I Atava, R Pečulis, I Elbere, L Ansone… - International Journal of …, 2024 - mdpi.com
Numerous type 2 diabetes (T2D) polygenic risk scores (PGSs) have been developed to
predict individuals' predisposition to the disease. An independent assessment and …
predict individuals' predisposition to the disease. An independent assessment and …
[HTML][HTML] Construction, evaluation, and AOP framework-based application of the EpPRS as a genetic surrogate for assessing environmental pollutants
S Chen, J Xin, Z Ding, L Zhao, S Ben, R Zheng… - Environment …, 2023 - Elsevier
Background Environmental pollutant measurement is essential for accurate health risk
assessment. However, the detection of humans' internal exposure to pollutants is cost …
assessment. However, the detection of humans' internal exposure to pollutants is cost …
Factorizing polygenic epistasis improves prediction and uncovers biological pathways in complex traits
Epistasis is central in many domains of biology, but it has not yet been proven useful for
understanding the etiology of complex traits. This is partly because complex-trait epistasis …
understanding the etiology of complex traits. This is partly because complex-trait epistasis …
Integration of risk factor polygenic risk score with disease polygenic risk score for disease prediction
H Jung, HU Jung, EJ Baek, SY Kwon, JO Kang… - Communications …, 2024 - nature.com
Polygenic risk score (PRS) is useful for capturing an individual's genetic susceptibility.
However, previous studies have not fully exploited the potential of the risk factor PRS …
However, previous studies have not fully exploited the potential of the risk factor PRS …
Single-versus multi-ancestry polygenic risk scores for CKD in black Americans
AC Jones, A Patki… - Journal of the …, 2024 - journals.lww.com
Background: Chronic kidney disease (CKD) is a risk factor for cardiovascular disease and
early death. Recently, polygenic risk scores (PRS) have been developed to quantify risk for …
early death. Recently, polygenic risk scores (PRS) have been developed to quantify risk for …