The removal of introns from mRNA precursors and its regulation by alternative splicing are
key for eukaryotic gene expression and cellular function, as evidenced by the numerous …

The collection of components required to carry out the intricate processes involved in
generating and maintaining a living, breathing and, sometimes, thinking organism is …

The splicing of pre‐mRNAs is an essential step of gene expression in eukaryotes. Introns
are removed from split genes through the activities of the spliceosome, a large ribonuclear …

Machine learning methods, particularly neural networks trained on large datasets, are
transforming how scientists approach scientific discovery and experimental design …

What makes a nucleotide sequence an exon (or an intron) is a question that still lacks a
satisfactory answer. Indeed, most eukaryotic genes are full of sequences that look like …

Pathogenic variants in the ATP‐binding cassette transporter A4 (ABCA4) gene cause a
continuum of retinal disease phenotypes, including Stargardt disease. Noncanonical splice …

Synthetic riboswitches are a versatile class of regulatory elements that are becoming
increasingly established in synthetic biology applications. They are characterized by their …

Effective splice site selection is critically controlled by flanking splicing regulatory elements
(SREs) that can enhance or repress splice site use. Although several computational …

MYC is dysregulated in> 50% of cancers, but direct targeting of MYC has been clinically
unsuccessful. Targeting downstream MYC effector pathways represents an attractive …

A gene's “expression profile” denotes the number of transcripts present relative to all other
transcripts. The overall rate of transcript production is determined by transcription and RNA …