Matrix metalloproteinases (MMPs) are a family of zinc-dependent extracellular matrix (ECM)
remodeling endopeptidases that have the capacity to degrade almost every component of …

Membrane-type matrix metalloproteinases (MT-MMPs) form a subgroup of the matrix
metalloproteinase (MMP) family, and there are 6 MT-MMPs in humans. MT-MMPs are further …

The mechanisms underlying the pathogenesis of multiple sclerosis induce the changes that
underpin relapse-associated and progressive disability. Disease mechanisms can be …

Human matrix metalloproteinases (MMPs) belong to the M10 family of the MA clan of
endopeptidases. They are ubiquitarian enzymes, structurally characterized by an active site …

Multiple sclerosis (MS) is a relatively common and etiologically unknown disease with no
cure treatment. It is the leading cause of neurological disability in young adults, affecting …

Background Detecting candidate B-cell epitopes in a protein is a basic and fundamental
step in many immunological applications. Due to the impracticality of experimental …

Galectin-3 (Gal-3) is the only chimeric protein in the galectin family. Gal-3 structure
comprises unusual tandem repeats of proline and glycine-rich short stretches bound to a …

Oligodendrocyte precursor cells (OPC) are glial cells that metamorphose into myelinating
oligodendrocytes during embryogenesis and early stages of post-natal life. OPCs continue …

Understanding the physiological role of any protease requires identification of both its
cleavage substrates and their relative cleavage efficacy as compared with other substrates …

The neutrophil-specific protease membrane-type 6 matrix metalloproteinase (MT6-
MMP)/MMP-25/leukolysin is implicated in multiple sclerosis and cancer yet remains poorly …