The advent of fluorescent proteins (FPs) for genetic labeling of molecules and cells has
revolutionized fluorescence microscopy. Genetic manipulations have created a vast array of …

The purpose of this review is to give a comprehensive overview of transgenic mouse lines
suitable for studying gene function and cellular lineage relationships in lung development …

Regulation of cell differentiation programs requires complex interactions between
transcriptional and epigenetic networks. Elucidating the principal molecular events …

Gene network transitions in embryos and other fate-changing contexts involve combinations
of transcription factors. A subset of fate-changing transcription factors act as pioneers; they …

The mouse genetics toolkit: revealing function and mechanism | Genome Biology Skip to
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The generation of pancreas, liver, and intestine from a common pool of progenitors in the
foregut endoderm requires the establishment of organ boundaries. How dorsal foregut …

SET domain-containing proteins play a vital role in regulating gene expression during
development through modifications in chromatin structure. Here we show that SET domain …

Stem cell differentiation depends on transcriptional activation driven by lineage‐specific
regulators as well as changes in chromatin organization. However, the coordination of these …

The mechanisms that restrict regeneration and maintain cell identity following injury are
poorly characterized in higher vertebrates. Following β-cell loss, 1–2% of the glucagon …

Pancreatic islet cells provide the major source of counteractive endocrine hormones
required for maintaining glucose homeostasis; severe health problems result when these …