Neuroinflammation through the vagus nerve-dependent gut–microbiota–brain axis in treatment-resistant depression

K Hashimoto - Progress in Brain Research, 2023 - Elsevier
Neuroinflammation plays a key role in the pathogenesis of major depressive disorder
(MDD), including treatment-resistant depression (TRD). Patients with TRD have higher …

Are “mystical experiences” essential for antidepressant actions of ketamine and the classic psychedelics?

K Hashimoto - European Archives of Psychiatry and Clinical …, 2024 - Springer
The growing interest in the rapid and sustained antidepressant effects of the dissociative
anesthetic ketamine and classic psychedelics, such as psilocybin, is remarkable. However …

Neuromodulatory control of complex adaptive dynamics in the brain

JM Shine - Interface focus, 2023 - royalsocietypublishing.org
How is the massive dimensionality and complexity of the microscopic constituents of the
nervous system brought under sufficiently tight control so as to coordinate adaptive …

Psilocybin increases optimistic engagement over time: computational modelling of behaviour in rats

EL Fisher, R Smith, K Conn, AW Corcoran… - Translational …, 2024 - nature.com
Psilocybin has shown promise as a novel pharmacological intervention for treatment of
depression, where post-acute effects of psilocybin treatment have been associated with …

[HTML][HTML] Repeated use of 3, 4-methylenedioxymethamphetamine is associated with the resilience in mice after chronic social defeat stress: a role of gut–microbiota …

Y Qu, A Eguchi, X Wan, L Ma, L Chang, J Shan… - Psychiatry …, 2023 - Elsevier
Methylenedioxymethamphetamine (MDMA), the most widely used illicit compound
worldwide, is the most attractive therapeutic drug for post-traumatic stress disorder (PTSD) …

Role of the gut–brain axis via the subdiaphragmatic vagus nerve in stress resilience of 3, 4-methylenedioxymethamphetamine in mice exposed to chronic restrain …

Y Qu, A Eguchi, L Ma, X Wan, C Mori… - Neurobiology of Disease, 2023 - Elsevier
Methylenedioxymethamphetamine (MDMA) is the most widely used illicit substance
worldwide. Nevertheless, recent observational studies demonstrated that lifetime MDMA use …

Body as first teacher: The role of rhythmic visceral dynamics in early cognitive development

AW Corcoran, K Perrykkad… - Perspectives on …, 2023 - journals.sagepub.com
Embodied cognition—the idea that mental states and processes should be understood in
relation to one's bodily constitution and interactions with the world—remains a controversial …

A role for the serotonin 2A receptor in the expansion and functioning of human transmodal cortex

AI Luppi, M Girn, FE Rosas, C Timmermann… - Brain, 2024 - academic.oup.com
Integrating independent but converging lines of research on brain function and
neurodevelopment across scales, this article proposes that serotonin 2A receptor (5-HT2AR) …

Modulating arousal to overcome gait impairments in Parkinson's disease: how the noradrenergic system may act as a double-edged sword

A Tosserams, BR Bloem, KA Ehgoetz Martens… - Translational …, 2023 - Springer
In stressful or anxiety-provoking situations, most people with Parkinson's disease (PD)
experience a general worsening of motor symptoms, including their gait impairments …

From brain-body function to conscious interactions

CM Signorelli, JD Boils, E Tagliazucchi… - Neuroscience & …, 2022 - Elsevier
In this review, we discuss empirical results inspiring the introduction of a formal
mathematical multilayer model for the biological neuroscience of conscious experience …